TY - JOUR
T1 - Disorders of Calcium and Phosphorus Metabolism and the Proteomics/Metabolomics-Based Research
AU - Sun, Meiheng
AU - Wu, Xiaoqiu
AU - Yu, Yuanyuan
AU - Wang, Luyao
AU - Xie, Duoli
AU - Zhang, Zhenlin
AU - Chen, Lin
AU - Lu, Aiping
AU - Zhang, Ge
AU - Li, Fangfei
N1 - Funding Information:
This study was supported by the National Key Research and Development Program of China (2018YFA0800804), the Interdisciplinary Research Matching Scheme Hong Kong Baptist University (RC-IRMS/15-16/01), the Hong Kong General Research Fund (12101018, 12102518), and the National Natural Science Foundation Council of China (81703049). Sincere thanks should go to the other academic and staff members in AL and GZ’s group at Hong Kong Baptist University. We also thank Hong Kong Baptist University for providing critical comments and technical support.
Publisher copyright:
© 2020 Sun, Wu, Yu, Wang, Xie, Zhang, Chen, Lu, Zhang and Li. All rights reserved.
PY - 2020/9/10
Y1 - 2020/9/10
N2 - Since calcium and phosphorus play vital roles in a multitude of physiologic systems, disorders of calcium and phosphorus metabolism always lead to severe consequences such as skeletal-related and cardiovascular morbidity, or even life-threatening. Physiologically, the maintenance of calcium and phosphorus homeostasis is achieved via a variety of concerted actions of hormones such as parathyroid hormone (PTH), vitamin D, and fibroblast growth factor (FGF23), which could be regulated mainly at three organs, the intestine, kidney, and bone. Disruption of any organ or factor might lead to disorders of calcium and phosphorus metabolism. Currently, lacking of accurate diagnostic approaches and unknown molecular basis of pathophysiology will result in patients being unable to receive a precise diagnosis and personalized treatment timely. Therefore, it is urgent to identify early diagnostic biomarkers and develop therapeutic strategies. Fortunately, proteomics and metabolomics offer promising tools to discover novel indicators and further understanding of pathological mechanisms. Therefore, in this review, we will give a systematic introduction on PTH-1,25(OH)2D-FGF23 axis in the disorders of calcium and phosphorus metabolism, diagnostic biomarkers identified, and potential altered metabolic pathways involved.
AB - Since calcium and phosphorus play vital roles in a multitude of physiologic systems, disorders of calcium and phosphorus metabolism always lead to severe consequences such as skeletal-related and cardiovascular morbidity, or even life-threatening. Physiologically, the maintenance of calcium and phosphorus homeostasis is achieved via a variety of concerted actions of hormones such as parathyroid hormone (PTH), vitamin D, and fibroblast growth factor (FGF23), which could be regulated mainly at three organs, the intestine, kidney, and bone. Disruption of any organ or factor might lead to disorders of calcium and phosphorus metabolism. Currently, lacking of accurate diagnostic approaches and unknown molecular basis of pathophysiology will result in patients being unable to receive a precise diagnosis and personalized treatment timely. Therefore, it is urgent to identify early diagnostic biomarkers and develop therapeutic strategies. Fortunately, proteomics and metabolomics offer promising tools to discover novel indicators and further understanding of pathological mechanisms. Therefore, in this review, we will give a systematic introduction on PTH-1,25(OH)2D-FGF23 axis in the disorders of calcium and phosphorus metabolism, diagnostic biomarkers identified, and potential altered metabolic pathways involved.
KW - PTH-1
KW - biomarkers
KW - disorders of calcium and phosphorus metabolism
KW - metabolomics
KW - proteomics
KW - 25(OH)2D-FGF23 axis
UR - http://www.scopus.com/inward/record.url?scp=85091482124&partnerID=8YFLogxK
U2 - 10.3389/fcell.2020.576110
DO - 10.3389/fcell.2020.576110
M3 - Journal article
AN - SCOPUS:85091482124
SN - 2296-634X
VL - 8
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 576110
ER -