@article{36c03d0784fa4f6fbaea41bb42489af2,
title = "Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity via structure-based virtual screening",
abstract = "We describe herein compound 1, which is similar to many known natural products, as an inhibitor of the VHL-HIF1α interaction via structure-based virtual screening. Compound 1 disrupts VHL-mediated HIF1α degradation, leading to significantly increased VEGF expression. To our knowledge, compound 1 is a member of only the second class of small molecule inhibitors of the VHL-HIF1α interaction.",
author = "Chao Yang and Wanhe Wang and Linmin Chen and Jiaxin Liang and Sheng Lin and Lee, {Ming Yuen} and Ma, {Dik Lung} and Leung, {Chung Hang}",
note = "Funding Information: This work was supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU/12301115, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme(A-HKBU201/12-Oligoswitch), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), (MYRG2015-00137-ICMSQRCM, MRG044/LCH/2015/ICMS). Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2016",
year = "2016",
month = nov,
day = "11",
doi = "10.1039/c6cc04938a",
language = "English",
volume = "52",
pages = "12837--12840",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "87",
}
