@article{16a6267027b34ffcab6372b031340144,
title = "Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo",
abstract = "In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS. The iNOS inhibitory activity of the hit compounds was characterized using cellular assays and an in vivo zebrafish larvae model. The natural product-like compound 1 inhibited NO production in LPS-stimulated Raw264.7 macrophages, without exerting cytotoxic effects on the cells. Significantly, compound 1 was able to reverse MPTP-induced locomotion deficiency and neurotoxicity in an in vivo zebrafish larval model. Hence, compound 1 could be considered as a scaffold for the further development of iNOS inhibitors for potential anti-inflammatory or anti-neurodegenerative applications.",
author = "Zhong, \{Hai Jing\} and Liu, \{Li Juan\} and Chong, \{Cheong Meng\} and Lihua Lu and Modi Wang and Chan, \{Daniel Shiu Hin\} and Chan, \{Philip Wai Hong\} and Lee, \{Simon Ming Yuen\} and MA, \{Edmond Dik Lung\} and Leung, \{Chung Hang\}",
note = "This work is supported by Hong Kong Baptist University (FRG2/12-13/021), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (001/2012/A and 103/2012/A3) and the University of Macau (MYRG091(Y2-L2)-ICMS12-LCH, MYRG121(Y2-L2)-ICMS12-LCH and MRG023/LCH/2013/ICMS). ",
year = "2014",
month = apr,
day = "1",
doi = "10.1371/journal.pone.0092905",
language = "English",
volume = "9",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",
}
