Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening

Keyphrases

• Structure-based Virtual Screening 100%
• Target Molecule 100%
• Natural Inhibitors 100%
• NEDD8-activating Enzyme 100%
• Protein Neddylation 100%
• Molecular Targets 20%
• Cell-based 20%
• Protein Degradation 20%
• Enzyme Activity 20%
• Natural Products 20%
• Anticancer Drugs 20%
• Molecular Modeling 20%
• Modeling Results 20%
• Virtual Screening 20%
• Molecular Docking Analysis 20%
• Dipeptide 20%
• Cell-free 20%
• Non-covalent 20%
• Competitive Inhibitor 20%
• Scientific Community 20%
• Bioactive Scaffolds 20%
• Cullin-RING 20%
• Deoxyvasicinone 20%
• Specific Degradation 20%
• E3 Ubiquitin Ligase 20%
• ATP-binding Domain 20%
• ZINC Database 20%
• E1 Enzyme 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Natural Product 100%
• Virtual Screening 100%
• Molecular Target 50%
• Anticarcinogen 50%
• Adenosine Triphosphate 50%
• Dipeptide 50%
• Enzyme Inhibitor 50%
• Competitive Inhibitor 50%
• Ubiquitin Protein Ligase E3 50%
• Cullin 50%