Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

Silvio Aime; Alessandro Barge; Mauro Botta; Alvaro S. De Sousa; David Parker

doi:10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-%23

Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

Silvio Aime^*
, Alessandro Barge
, Mauro Botta
, Alvaro S. De Sousa
, David Parker

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

145 Citations (Scopus)

Abstract

A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III) complex with an octadentate, neutral macrocyclic ligand (k(ex)(M) < k(ex)(m)). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging.

Original language	English
Pages (from-to)	2673-2675
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	37
Issue number	19
DOIs	https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-%23
Publication status	Published - 16 Oct 1998

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User-Defined Keywords

Lanthanides
Macrocyclic ligands
NMR spectroscopy
Water exchange

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10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-%23

Cite this

@article{90238a0c52804c0ea9ceb51eb20b3b98,

title = "Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes",

abstract = "A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III) complex with an octadentate, neutral macrocyclic ligand (k(ex)(M) < k(ex)(m)). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging.",

keywords = "Lanthanides, Macrocyclic ligands, NMR spectroscopy, Water exchange",

author = "Silvio Aime and Alessandro Barge and Mauro Botta and \{De Sousa\}, \{Alvaro S.\} and David Parker",

note = "Publisher copyright: {\textcopyright} 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany",

year = "1998",

month = oct,

day = "16",

doi = "10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-\%23",

language = "English",

volume = "37",

pages = "2673--2675",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley \& Sons Ltd",

number = "19",

}

Aime, S, Barge, A, Botta, M, De Sousa, AS & Parker, D 1998, 'Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes', Angewandte Chemie - International Edition, vol. 37, no. 19, pp. 2673-2675. https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-%23

Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes. / Aime, Silvio; Barge, Alessandro; Botta, Mauro et al.
In: Angewandte Chemie - International Edition, Vol. 37, No. 19, 16.10.1998, p. 2673-2675.

Research output: Contribution to journal › Journal article › peer-review

TY - JOUR

T1 - Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

AU - Aime, Silvio

AU - Barge, Alessandro

AU - Botta, Mauro

AU - De Sousa, Alvaro S.

AU - Parker, David

PY - 1998/10/16

Y1 - 1998/10/16

N2 - A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III) complex with an octadentate, neutral macrocyclic ligand (k(ex)(M) < k(ex)(m)). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging.

AB - A large difference in the exchange rate of the coordinated water molecule is seen in solution for the diastereoisomers M and m of a europium(III) complex with an octadentate, neutral macrocyclic ligand (k(ex)(M) < k(ex)(m)). This finding is of high relevance to the design of more efficient contrast agents for magnetic resonance imaging.

KW - Lanthanides

KW - Macrocyclic ligands

KW - NMR spectroscopy

KW - Water exchange

UR - https://www.scopus.com/pages/publications/0032538573

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000076575900017?KeyUID=WOS:000076575900017

U2 - 10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-%23

DO - 10.1002/(sici)1521-3773(19981016)37:19<2673::aid-anie2673>3.0.co;2-%23

M3 - Journal article

AN - SCOPUS:0032538573

SN - 1433-7851

VL - 37

SP - 2673

EP - 2675

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 19

ER -

Direct NMR Spectroscopic Observation of a Lanthanide-Coordinated Water Molecule whose Exchange Rate Is Dependent on the Conformation of the Complexes

Abstract

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