@article{59acc5977cba4a009447025dc051e7ea,
title = "Direct Construction of Corrole-peptide Conjugates by Controllable Bilane Formation on Resin",
abstract = "Corroles have attracted increasing research interests in recent decades owing to their unique properties over porphyrins. However, the relatively inefficient and tedious synthetic procedures of corrole building blocks with functional groups for bioconjugation hindered their bioapplications. Herein, we report a highly efficient protocol to synthesize corrole-peptide conjugates with good yields (up to 63 %) without using prepared corrole building blocks. By condensing two -COOH-bearing-dipyrromethane molecules onto an aldehyde group on resin-bound peptide chains in a controllable manner, a series of desired products with long (up to 25 residues) and bioactive peptide chains were obtained with at most one chromatographic purification. The synthesized compounds exhibited potential applications as chelators for metal ions for biomedical applications, as building blocks for supramolecular materials, as well as targeted fluorescent probes.",
keywords = "Corrole, Corrole-peptide conjugates, Latent membrane protein 1, Solid-phase peptide synthesis, Targeted Bioimaging",
author = "Yue Wu and Ho-Fai Chau and Hei-Yui Kai and Wing-Sze Tam and Yik-Hoi Yeung and Waygen Thor and Tsz-Lam Cheung and Chen Xie and Jing-Xiang Zhang and Ka-Leung Wong",
note = "Funding Information: Financial assistances from the Hong Kong Research Grants Council No. 12300021, NSFC/RGC Joint Research Scheme (N_HKBU209/21), Dr. Mok Man Hung Endowed Professorship in Chemistry, HKBU-Durham Lanthanide Joint Research Center – Lanthanide Tools for Systems Medicine (SDF19-1011-P02) and the Centre for Medical Engineering of Molecular and Biological Probes (AoE/M-401/20) are gratefully acknowledged (K.-L.W). J.-X.Z. acknowledged the financial assistance from Guangdong Basic and Applied Basic Research Foundation (No. 2021A1515012358). The precious advice in writing provided by Dr. Wai-Sum Lo from the Department of Applied Biology and Chemical Technology (ABCT) of The Hong Kong Polytechnic University (HKPolyU) is greatly appreciated. We also appreciate the service of high-resolution mass spectrometry provided by The University Research Facility in Life Sciences (ULS) of HKPolyU. Publisher copyright: {\textcopyright} 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH ",
year = "2023",
month = may,
day = "2",
doi = "10.1002/chem.202203623",
language = "English",
volume = "29",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "25",
}