Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage

Biquan Xiong; Longzhi Zhu; Xiaofeng Feng; Jian Lei; Tieqiao Chen; Yongbo Zhou; Li Biao Han; Chak Tong Au; Shuang Feng Yin

doi:10.1002/ejoc.201402332

Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage

Biquan Xiong
, Longzhi Zhu
, Xiaofeng Feng
, Jian Lei
, Tieqiao Chen
, Yongbo Zhou^*
, Li Biao Han
, Chak Tong Au
, Shuang Feng Yin

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

30 Citations (Scopus)

Abstract

A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.

Original language	English
Pages (from-to)	4244-4247
Number of pages	4
Journal	European Journal of Organic Chemistry
Volume	2014
Issue number	20
DOIs	https://doi.org/10.1002/ejoc.201402332
Publication status	Published - Jul 2014

User-Defined Keywords

Amidation
Amines
Carboxylic acids
Cleavage reactions
Copper
Synthetic methods

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10.1002/ejoc.201402332

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title = "Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage",

abstract = "A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.",

keywords = "Amidation, Amines, Carboxylic acids, Cleavage reactions, Copper, Synthetic methods",

author = "Biquan Xiong and Longzhi Zhu and Xiaofeng Feng and Jian Lei and Tieqiao Chen and Yongbo Zhou and Han, \{Li Biao\} and Au, \{Chak Tong\} and Yin, \{Shuang Feng\}",

year = "2014",

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pages = "4244--4247",

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TY - JOUR

T1 - Direct amidation of carboxylic acids with tertiary amines

T2 - Amide formation over copper catalysts through C-N bond cleavage

AU - Xiong, Biquan

AU - Zhu, Longzhi

AU - Feng, Xiaofeng

AU - Lei, Jian

AU - Chen, Tieqiao

AU - Zhou, Yongbo

AU - Han, Li Biao

AU - Au, Chak Tong

AU - Yin, Shuang Feng

PY - 2014/7

Y1 - 2014/7

N2 - A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.

AB - A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.

KW - Amidation

KW - Amines

KW - Carboxylic acids

KW - Cleavage reactions

KW - Copper

KW - Synthetic methods

UR - https://www.scopus.com/pages/publications/84903795621

U2 - 10.1002/ejoc.201402332

DO - 10.1002/ejoc.201402332

M3 - Journal article

AN - SCOPUS:84903795621

SN - 1434-193X

VL - 2014

SP - 4244

EP - 4247

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 20

ER -

Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage

Abstract

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