TY - JOUR
T1 - Dioscorea nipponica Makino
T2 - a systematic review on its ethnobotany, phytochemical and pharmacological profiles
AU - Ou-Yang, Si hong
AU - Jiang, Tao
AU - Zhu, Lin
AU - YI, Tao
N1 - Funding Information:
This work was the Guangdong Natural Science Foundation (2016A030313008) and the Shenzhen Science and Technology Innovation Committee (JCYJ20160518094706544).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Dioscorea nipponica Makino is a perennial twining herbs belonging to the family Dioscoreaceae, which is mainly distributed in the northeastern, northern, eastern and central regions of China. Traditionally, the rhizome of this herb has been commonly used by Miao and Meng ethnic groups of China to treat rheumatoid arthritis, pain in the legs and lumbar area, Kashin Beck disease, bruises, sprains, chronic bronchitis, cough and asthma. Modern pharmacological studies have discovered that this herb possesses anti-tumor, anti-inflammatory, anti-diuretic, analgesic, anti-tussive, panting-calming and phlegm-dispelling activities, along with enhancing immune function and improving cardiovascular health. In recent years, both fat-soluble and water-soluble steroidal saponins were isolated from the rhizomes of D. nipponica using silica gel column chromatography, thin layer chromatography and high performance liquid chromatography methods. Saponin and sapogenins are mainly responsible for most of the pharmacological effects of this plant. Further, the chemical components of the aboveground parts contain more than 10 kinds of phenanthrene derivatives. The present review summarizes the knowledge concerning the geographical distribution, chemical composition, pharmacological effects, toxicology studies and clinical applications of D. nipponica. [Figure not available: see fulltext.].
AB - Dioscorea nipponica Makino is a perennial twining herbs belonging to the family Dioscoreaceae, which is mainly distributed in the northeastern, northern, eastern and central regions of China. Traditionally, the rhizome of this herb has been commonly used by Miao and Meng ethnic groups of China to treat rheumatoid arthritis, pain in the legs and lumbar area, Kashin Beck disease, bruises, sprains, chronic bronchitis, cough and asthma. Modern pharmacological studies have discovered that this herb possesses anti-tumor, anti-inflammatory, anti-diuretic, analgesic, anti-tussive, panting-calming and phlegm-dispelling activities, along with enhancing immune function and improving cardiovascular health. In recent years, both fat-soluble and water-soluble steroidal saponins were isolated from the rhizomes of D. nipponica using silica gel column chromatography, thin layer chromatography and high performance liquid chromatography methods. Saponin and sapogenins are mainly responsible for most of the pharmacological effects of this plant. Further, the chemical components of the aboveground parts contain more than 10 kinds of phenanthrene derivatives. The present review summarizes the knowledge concerning the geographical distribution, chemical composition, pharmacological effects, toxicology studies and clinical applications of D. nipponica. [Figure not available: see fulltext.].
KW - Active ingredient
KW - Dioscorea nipponica Makino
KW - Geographical distribution
KW - Pharmacological studies
KW - Steroid saponins
UR - http://www.scopus.com/inward/record.url?scp=85046853349&partnerID=8YFLogxK
U2 - 10.1186/s13065-018-0423-4
DO - 10.1186/s13065-018-0423-4
M3 - Review article
AN - SCOPUS:85046853349
VL - 12
JO - Chemistry Central Journal
JF - Chemistry Central Journal
SN - 1752-153X
IS - 1
M1 - 57
ER -