TY - JOUR
T1 - Dioscorea nipponica Makino
T2 - a systematic review on its ethnobotany, phytochemical and pharmacological profiles
AU - Ou-Yang, Si hong
AU - Jiang, Tao
AU - Zhu, Lin
AU - Yi, Tao
N1 - Funding Information:
This work was the Guangdong Natural Science Foundation (2016A030313008) and the Shenzhen Science and Technology Innovation Committee (JCYJ20160518094706544).
Publisher copyright:
© The Author(s) 2018
PY - 2018/5/11
Y1 - 2018/5/11
N2 - Dioscorea nipponica Makino is a perennial twining herbs belonging
to the family Dioscoreaceae, which is mainly distributed in the
northeastern, northern, eastern and central regions of China.
Traditionally, the rhizome of this herb has been commonly used by Miao
and Meng ethnic groups of China to treat rheumatoid arthritis, pain in
the legs and lumbar area, Kashin Beck disease, bruises, sprains, chronic
bronchitis, cough and asthma. Modern pharmacological studies have
discovered that this herb possesses anti-tumor, anti-inflammatory,
anti-diuretic, analgesic, anti-tussive, panting-calming and
phlegm-dispelling activities, along with enhancing immune function and
improving cardiovascular health. In recent years, both fat-soluble and
water-soluble steroidal saponins were isolated from the rhizomes of D. nipponica
using silica gel column chromatography, thin layer chromatography and
high performance liquid chromatography methods. Saponin and sapogenins
are mainly responsible for most of the pharmacological effects of this
plant. Further, the chemical components of the aboveground parts contain
more than 10 kinds of phenanthrene derivatives. The present review
summarizes the knowledge concerning the geographical distribution,
chemical composition, pharmacological effects, toxicology studies and
clinical applications of D. nipponica.
AB - Dioscorea nipponica Makino is a perennial twining herbs belonging
to the family Dioscoreaceae, which is mainly distributed in the
northeastern, northern, eastern and central regions of China.
Traditionally, the rhizome of this herb has been commonly used by Miao
and Meng ethnic groups of China to treat rheumatoid arthritis, pain in
the legs and lumbar area, Kashin Beck disease, bruises, sprains, chronic
bronchitis, cough and asthma. Modern pharmacological studies have
discovered that this herb possesses anti-tumor, anti-inflammatory,
anti-diuretic, analgesic, anti-tussive, panting-calming and
phlegm-dispelling activities, along with enhancing immune function and
improving cardiovascular health. In recent years, both fat-soluble and
water-soluble steroidal saponins were isolated from the rhizomes of D. nipponica
using silica gel column chromatography, thin layer chromatography and
high performance liquid chromatography methods. Saponin and sapogenins
are mainly responsible for most of the pharmacological effects of this
plant. Further, the chemical components of the aboveground parts contain
more than 10 kinds of phenanthrene derivatives. The present review
summarizes the knowledge concerning the geographical distribution,
chemical composition, pharmacological effects, toxicology studies and
clinical applications of D. nipponica.
KW - Active ingredient
KW - Dioscorea nipponica Makino
KW - Geographical distribution
KW - Pharmacological studies
KW - Steroid saponins
UR - http://www.scopus.com/inward/record.url?scp=85046853349&partnerID=8YFLogxK
U2 - 10.1186/s13065-018-0423-4
DO - 10.1186/s13065-018-0423-4
M3 - Review article
AN - SCOPUS:85046853349
VL - 12
JO - Chemistry Central Journal
JF - Chemistry Central Journal
SN - 1752-153X
M1 - 57
ER -