Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis

Ze Si Lin, Chuen Fai KU, Yifu GUAN, Haitao XIAO, Xiao Ke Shi, Hong Qi Wang, Zhaoxiang BIAN, Siu Wai TSANG*, Hongjie ZHANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Acute pancreatitis is an inflammatory process originated in the pancreas; however, it often leads to systemic complications that affect distant organs. Acute respiratory distress syndrome is indeed the predominant cause of death in patients with severe acute pancreatitis. In this study, we aimed to delineate the ameliorative effect of dihydro-resveratrol, a prominent analog of trans-resveratrol, against acute pancreatitis-associated lung injury and the underlying molecular actions. Acute pancreatitis was induced in rats with repetitive injections of cerulein (50 μg/kg/h) and a shot of lipopolysaccharide (7.5 mg/kg). By means of histological examination and biochemical assays, the severity of lung injury was assessed in the aspects of tissue damages, myeloperoxidase activity, and levels of pro-inflammatory cytokines. When treated with dihydro-resveratrol, pulmonary architectural distortion, hemorrhage, interstitial edema, and alveolar thickening were significantly reduced in rats with acute pancreatitis. In addition, the production of pro-inflammatory cytokines and the activity of myeloperoxidase in pulmonary tissues were notably repressed. Importantly, nuclear factor-kappaB (NF-κB) activation was attenuated. This study is the first to report the oral administration of dihydro-resveratrol ameliorated acute pancreatitis-associated lung injury via an inhibitory modulation of pro-inflammatory response, which was associated with a suppression of the NF-κB signaling pathway.

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalPhytotherapy Research
Volume30
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

Scopus Subject Areas

  • Pharmacology

User-Defined Keywords

  • acute pancreatitis
  • acute pancreatitis-associated lung injury
  • cerulein
  • dihydro-resveratrol
  • pro-inflammatory cytokines
  • trans-resveratrol

Fingerprint

Dive into the research topics of 'Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis'. Together they form a unique fingerprint.

Cite this