Different durations of cognitive stimulation therapy for Alzheimer’s disease: A systematic review and meta-analysis

Juexuan Chen; Yuting Duan; Huanjie Li; Liming Lu; Jihong Liu; Chunzhi Tang

doi:10.2147/CIA.S210062

Different durations of cognitive stimulation therapy for Alzheimer’s disease: A systematic review and meta-analysis

Juexuan Chen, Yuting Duan, Huanjie Li, Liming Lu, Jihong Liu^*, Chunzhi Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer’s disease (AD).

Methods: A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool.

Results: Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST.

Conclusion: Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.

Original language	English
Pages (from-to)	1243-1254
Number of pages	12
Journal	Clinical Interventions in Aging
Volume	14
DOIs	https://doi.org/10.2147/CIA.S210062
Publication status	Published - 12 Jul 2019

User-Defined Keywords

Alzheimer’s disease
Cognitive stimulation therapy
Cognitive symptom
Meta-analysis

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10.2147/CIA.S210062

https://www.dovepress.com/different-durations-of-cognitive-stimulation-therapy-for-alzheimers-di-peer-reviewed-fulltext-article-CIA

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title = "Different durations of cognitive stimulation therapy for Alzheimer{\textquoteright}s disease: A systematic review and meta-analysis",

abstract = "Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer{\textquoteright}s disease (AD).Methods: A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool.Results: Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST.Conclusion: Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.",

keywords = "Alzheimer{\textquoteright}s disease, Cognitive stimulation therapy, Cognitive symptom, Meta-analysis",

author = "Juexuan Chen and Yuting Duan and Huanjie Li and Liming Lu and Jihong Liu and Chunzhi Tang",

note = "Funding information: This work was supported by National Natural Science Foundation of China (Project No. 81873375). Juexuan Chen and Yuting Duan should be considered joint senior authors for this study. Publisher Copyright: {\textcopyright} 2019 Chen et al.",

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doi = "10.2147/CIA.S210062",

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T2 - A systematic review and meta-analysis

AU - Chen, Juexuan

AU - Duan, Yuting

AU - Li, Huanjie

AU - Lu, Liming

AU - Liu, Jihong

AU - Tang, Chunzhi

N1 - Funding information: This work was supported by National Natural Science Foundation of China (Project No. 81873375). Juexuan Chen and Yuting Duan should be considered joint senior authors for this study. Publisher Copyright: © 2019 Chen et al.

PY - 2019/7/12

Y1 - 2019/7/12

N2 - Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer’s disease (AD).Methods: A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool.Results: Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST.Conclusion: Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.

AB - Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer’s disease (AD).Methods: A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental State Examination (MMSE) score. We conducted a meta-analysis with Review Manager, version 5.3 and assessed the methodological quality of the included studies using the Cochrane Collaboration Recommendations assessment tool.Results: Treatment effects from the meta-analysis showed that CST plus acetylcholinesterase inhibitors (ChEIs) was better than the control assessed by MMSE. In addition, the meta-analysis indicated that long-term CST was better than short-term or maintenance CST.Conclusion: Our study confirmed that the combination of CST and drug treatment for AD is effective in AD, regardless of whether short-term CST, maintenance CST, or long-term CST is used. The long-term CST appears to be more effective.

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Different durations of cognitive stimulation therapy for Alzheimer’s disease: A systematic review and meta-analysis

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