Dietary phytochemical approaches to stem cell regulation

Shuai Zhang; Kargo Kar Ho Lam; Jack Hei Wan; Chun Wang Yip; Harry Kwun Hung Liu; Queenie Ming Ngai Lau; Alice Hei Yi Man; Chun Hei Cheung; Lik Hang Wong; Hu Biao Chen; Jun Shi; George Par Heng Leung; Calvin Kai Fai Lee; Yi Gang Shi; Sydney Chi Wai Tang; Kalin Yan Bo Zhang

doi:10.1016/j.jff.2020.103822

Dietary phytochemical approaches to stem cell regulation

Shuai Zhang, Kargo Kar Ho Lam, Jack Hei Wan, Chun Wang Yip, Harry Kwun Hung Liu, Queenie Ming Ngai Lau, Alice Hei Yi Man, Chun Hei Cheung, Lik Hang Wong, Hu Biao Chen, Jun Shi, George Par Heng Leung, Calvin Kai Fai Lee, Yi Gang Shi, Sydney Chi Wai Tang^*, Kalin Yan Bo Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Citations (Scopus)

Abstract

Controlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases.

Original language	English
Article number	103822
Journal	Journal of Functional Foods
Volume	66
DOIs	https://doi.org/10.1016/j.jff.2020.103822
Publication status	Published - Mar 2020

Scopus Subject Areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

User-Defined Keywords

Differentiation
Phytochemical
Regenerative medicine
Self-renewal
Stem cell

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10.1016/j.jff.2020.103822

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Zhang, S., Lam, K. K. H., Wan, J. H., Yip, C. W., Liu, H. K. H., Lau, Q. M. N., Man, A. H. Y., Cheung, C. H., Wong, L. H., Chen, H. B., Shi, J., Leung, G. P. H., Lee, C. K. F., Shi, Y. G., Tang, S. C. W., & Zhang, K. Y. B. (2020). Dietary phytochemical approaches to stem cell regulation. Journal of Functional Foods, 66, Article 103822. https://doi.org/10.1016/j.jff.2020.103822

@article{e679d5a2fecc4406b2f21a9d8606c120,

title = "Dietary phytochemical approaches to stem cell regulation",

abstract = "Controlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases.",

keywords = "Differentiation, Phytochemical, Regenerative medicine, Self-renewal, Stem cell",

author = "Shuai Zhang and Lam, {Kargo Kar Ho} and Wan, {Jack Hei} and Yip, {Chun Wang} and Liu, {Harry Kwun Hung} and Lau, {Queenie Ming Ngai} and Man, {Alice Hei Yi} and Cheung, {Chun Hei} and Wong, {Lik Hang} and Chen, {Hu Biao} and Jun Shi and Leung, {George Par Heng} and Lee, {Calvin Kai Fai} and Shi, {Yi Gang} and Tang, {Sydney Chi Wai} and Zhang, {Kalin Yan Bo}",

note = "Funding Information: This work was financially supported by grants from Innovation and Technology Support Programme, Government of Hong Kong (Project code: UIM/321), and Seed Fund for Basic Research (Project code: 201611159232), University of Hong Kong. Publisher copyright: {\textcopyright} 2020 Elsevier Ltd.",

year = "2020",

month = mar,

doi = "10.1016/j.jff.2020.103822",

language = "English",

volume = "66",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Dietary phytochemical approaches to stem cell regulation

AU - Zhang, Shuai

AU - Lam, Kargo Kar Ho

AU - Wan, Jack Hei

AU - Yip, Chun Wang

AU - Liu, Harry Kwun Hung

AU - Lau, Queenie Ming Ngai

AU - Man, Alice Hei Yi

AU - Cheung, Chun Hei

AU - Wong, Lik Hang

AU - Chen, Hu Biao

AU - Shi, Jun

AU - Leung, George Par Heng

AU - Lee, Calvin Kai Fai

AU - Shi, Yi Gang

AU - Tang, Sydney Chi Wai

AU - Zhang, Kalin Yan Bo

N1 - Funding Information: This work was financially supported by grants from Innovation and Technology Support Programme, Government of Hong Kong (Project code: UIM/321), and Seed Fund for Basic Research (Project code: 201611159232), University of Hong Kong. Publisher copyright: © 2020 Elsevier Ltd.

PY - 2020/3

Y1 - 2020/3

N2 - Controlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases.

AB - Controlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases.

KW - Differentiation

KW - Phytochemical

KW - Regenerative medicine

KW - Self-renewal

KW - Stem cell

UR - http://www.scopus.com/inward/record.url?scp=85079534037&partnerID=8YFLogxK

U2 - 10.1016/j.jff.2020.103822

DO - 10.1016/j.jff.2020.103822

M3 - Review article

AN - SCOPUS:85079534037

SN - 1756-4646

VL - 66

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 103822

ER -

Dietary phytochemical approaches to stem cell regulation

Abstract

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