Dietary lipids and adipocytes: Potential therapeutic targets in cancers

Hiu Yee KWAN*, Xiaojuan Chao, Tao Su, Xiuqiong FU, Bin Liu, Anfernee K W TSE, David W F FONG, Zhiling YU

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Lipids play an important role to support the rapid growth of cancer cells, which can be derived from both the endogenous synthesis and exogenous supplies. Enhanced de novo fatty acid synthesis and mobilization of stored lipids in cancer cells promote tumorigenesis. Besides, lipids and fatty acids derived from diet or transferred from neighboring adipocytes also influence the proliferation and metastasis of cancer cells. Indeed, the pathogenic roles of adipocytes in the tumor microenvironment have been recognized recently. The adipocyte-derived mediators or the cross talk between adipocytes and cancer cells in the microenvironment is gaining attention. This review will focus on the impacts of lipids on cancers and the pathogenic roles of adipocytes in tumorigenesis and discuss the possible anticancer therapeutic strategies targeting lipids in the cancer cells.

Original languageEnglish
Pages (from-to)303-311
Number of pages9
JournalJournal of Nutritional Biochemistry
Volume26
Issue number4
DOIs
Publication statusPublished - 1 Apr 2015

Scopus Subject Areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry

User-Defined Keywords

  • Adipocytes
  • Cancer
  • Lipids
  • Microenvironment
  • Obesity

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