Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

Qibin Qi*, MK Downer, TO Kilpeläinen, HR Taal, SJ Barton, I Ntalla, M Standl, V Boraska, V Huikari, Jong JC Kiefte-de, A Körner, TA Lakka, G Liu, J Magnusson, M Okuda, O Raitakari, R Richmond, RA Scott, MES Bailey , K ScheuermannJW Holloway, H Inskip, CR Isasi, Y Mossavar-Rahmani, VWV Jaddoe, J Laitinen, V Lindi, E Melén, Yannis PITSILADIS, N Pitkänen, H Snieder, J Heinrich, NJ Timpson, Tao Wang, H Yuji, E Zeggini, GV Dedoussis, RC Kaplan, J Wylie-Rosett, RJF Loos, FB Hu, L Qi*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

79 Citations (Scopus)

Abstract

The FTO gene harbors variation with the strongest effect on adiposity and obesity risk. Previous data support a role for FTO variation in influencing food intake. We conducted a combined analysis of 16,094 boys and girls aged 1–18 years from 14 studies to examine the following: 1) the association between the FTO rs9939609 variant (or a proxy) and total energy and macronutrient intake; and 2) the interaction between the FTO variant and dietary intake, and the effect on BMI. We found that the BMI-increasing allele (minor allele) of the FTO variant was associated with increased total energy intake (effect per allele = 14.3 kcal/day [95% CI 5.9, 22.7 kcal/day], P = 6.5 × 10−4), but not with protein, carbohydrate, or fat intake. We also found that protein intake modified the association between the FTO variant and BMI (interactive effect per allele = 0.08 SD [0.03, 0.12 SD], P for interaction = 7.2 × 10−4): the association between FTO genotype and BMI was much stronger in individuals with high protein intake (effect per allele = 0.10 SD [0.07, 0.13 SD], P = 8.2 × 10−10) than in those with low intake (effect per allele = 0.04 SD [0.01, 0.07 SD], P = 0.02). Our results suggest that the FTO variant that confers a predisposition to higher BMI is associated with higher total energy intake, and that lower dietary protein intake attenuates the association between FTO genotype and adiposity in children and adolescents.

Original languageEnglish
Pages (from-to)2467-2476
Number of pages10
JournalDiabetes
Volume64
Issue number7
DOIs
Publication statusPublished - Feb 2015

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