TY - JOUR
T1 - Dietary exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans via fish consumption and dioxin-like activity in fish determined by H4IIE-luc bioassay
AU - Chan, Janet Kit Yan
AU - Man, Yu Bon
AU - Xing, Guan Hua
AU - Wu, Sheng Chun
AU - Murphy, Margaret B.
AU - Xu, Ying
AU - Wong, Ming H.
N1 - Funding Information:
This research was supported by The Research Grants Council of the University Grants Committee of Hong Kong (Central Allocation Group Research Project HKBU 1/03C ), the Match Fund from Hong Kong Baptist University , and a private donation.
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Dietary exposure to polychlorinated dibenzo. -p-dioxins and dibenzofurans (PCDD/Fs) via fish consumption in two major electronic (e) waste sites: Guiyu (GY), Guangdong Province and Taizhou (TZ), Zhejiang Province, and dioxin-like activity in fish determined by H4IIE-luc bioassay. In the present study, all fish were below EU's maximum allowable concentration in muscle of fish (4. pg WHO-TEQ/g wet wt), except crucian (4.28. pg WHO-TEQ/g wet wt) and silver carps (7.49. pg WHO-TEQ/g wet wt) collected from GY rivers. Moreover, the residual concentration in bighead carp collected from GY (2.15. pg WHO-TEQ/g wet wt) was close to the EU's action level (3. pg WHO-TEQ/g wet wt) which gives "early warning" to the competent authorities and operators to take measures to eliminate contamination. In addition, results indicated that the maximum human intake of PCDD/Fs via freshwater fish consumption in GY was 4.31. pg WHO-TEQ/kg bw/day, which exceeds the higher end of the tolerable daily intake recommended by the WHO, EC-SCF and JECFA (1-4, 2 and 2.3. pg WHO-TEQ/kg bw/day respectively). Furthermore, H4IIE-luc cell bioassay provides a very sensitive and cost-efficient screening tool for assessing the overall dioxin-like toxicity in the study, and is therefore valuable for high-throughput environmental monitoring studies.
AB - Dietary exposure to polychlorinated dibenzo. -p-dioxins and dibenzofurans (PCDD/Fs) via fish consumption in two major electronic (e) waste sites: Guiyu (GY), Guangdong Province and Taizhou (TZ), Zhejiang Province, and dioxin-like activity in fish determined by H4IIE-luc bioassay. In the present study, all fish were below EU's maximum allowable concentration in muscle of fish (4. pg WHO-TEQ/g wet wt), except crucian (4.28. pg WHO-TEQ/g wet wt) and silver carps (7.49. pg WHO-TEQ/g wet wt) collected from GY rivers. Moreover, the residual concentration in bighead carp collected from GY (2.15. pg WHO-TEQ/g wet wt) was close to the EU's action level (3. pg WHO-TEQ/g wet wt) which gives "early warning" to the competent authorities and operators to take measures to eliminate contamination. In addition, results indicated that the maximum human intake of PCDD/Fs via freshwater fish consumption in GY was 4.31. pg WHO-TEQ/kg bw/day, which exceeds the higher end of the tolerable daily intake recommended by the WHO, EC-SCF and JECFA (1-4, 2 and 2.3. pg WHO-TEQ/kg bw/day respectively). Furthermore, H4IIE-luc cell bioassay provides a very sensitive and cost-efficient screening tool for assessing the overall dioxin-like toxicity in the study, and is therefore valuable for high-throughput environmental monitoring studies.
KW - Electronic waste
KW - Estimated daily intake
KW - Freshwater fish
KW - H4IIE-luc cell bioassay
KW - PCDD/Fs
UR - http://www.scopus.com/inward/record.url?scp=84883453461&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2012.07.099
DO - 10.1016/j.scitotenv.2012.07.099
M3 - Journal article
C2 - 22959899
AN - SCOPUS:84883453461
SN - 0048-9697
VL - 463-464
SP - 1192
EP - 1200
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -