DHPG induced high frequency oscillations in cerebellar cortex in vivo

High frequency oscillations have been demonstrated in many areas of cerebral cortex to date. Oscillations, particularly those at gamma frequencies (3080Hz) are believed to provide a temporal code and promote the formation of neuronal assemblies, by permitting spatially separate subpopulations of neurons to fire synchronously (Gray &Singer,1989;Fries,2005). We recently demonstrated the induction by nicotine of gamma frequency (30-80 Hz) oscillations (>80 Hz) and very fast oscillations (VFOs, 80–160 Hz) in acute cerebellar slices (Middleton et al., 2008). Here we demonstrate that in response to group I mGluR activation by DHPG areas of cerebellar cortex (crus I &II) generate gamma frequency and very fast oscillations in vivo.