Developmental distribution of vestibular nuclear neurons responsive to different speeds of horizontal translation

Chun Wai Ma, Chun Hong Lai*, Suk King Lai, Yiu Chung Tse, Kin Lam YUNG, Daisy K.Y. Shum, Ying Shing Chan

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

3 Citations (Scopus)


To examine whether subgroups of vestibular nuclear neurons encode different frequency oscillation of horizontal linear motion, Fos immunohistochemistry was used to document neuronal subpopulations that were functionally activated by such otolithic stimulations. Conscious rats at P7, P14 and adult were subjected to sinusoidal linear acceleration along the transverse axis on the horizontal plane. Labyrinthectomized and/or stationary controls showed only sporadically scattered Fos-labeled neurons in the vestibular nuclei, confirming otolithic origin of c-fos expression. In each age group, Fos-labeled neurons responsive to high frequency stimulation (> 1.5 Hz) were clustered in the lateral region of the medial vestibular nucleus while those to low frequency stimulation (0.5-1.0 Hz) were found in the medial portion of the medial vestibular nucleus. The number of these neurons increased with age. No apparent frequency-related distribution pattern of Fos-labeled neurons was observed in other vestibular nuclei and subgroups. Our findings therefore reveal subpopulations of central vestibular neurons responsive to different stimulus frequencies that correspond to head motions ranging from tilt to translation.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalBrain Research
Publication statusPublished - 22 Apr 2010

Scopus Subject Areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

User-Defined Keywords

  • Fos
  • Immunocytohemistry
  • Linear acceleration
  • Utricle
  • Vestibular nuclei


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