@article{f61215ebb7cd4e2986336946cc4960c9,
title = "Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus",
abstract = "A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.",
author = "Lam, \{P. L.\} and Lu, \{G. L.\} and Hon, \{K. M.\} and Lee, \{K. W.\} and HO, \{Cheuk Lam\} and X. Wang and Tang, \{J. C.O.\} and Lam, \{K. H.\} and Wong, \{R. S.M.\} and Kok, \{S. H.L.\} and Zhaoxiang BIAN and H. Li and Lee, \{K. K.H.\} and R. Gambari and CHUI, \{Chung Hin\} and WONG, \{Wai Yeung\}",
note = "We acknowledge the financial support from the National Basic Research Program of China (973 Project 2013CB834702), a joint research grant under Innovation Technology Commission and Research Grants Council from PolyU, the research grants: 38-40-116 (Dr C. H. Chui) and 03-16-176 (Prof. Z. X. Bian), the Areas of Excellence Scheme from University Grants Committee of HKSAR (AoE/P-03/08), Hong Kong Research Grants Council (HKBU203011) and Hong Kong Baptist University (FRG2/11-12/156). H. Li also thanks the 985 Program and 111 Project from Minzu University of China (CUN985-07-08 and 111 Project B08044) for financial support. Prof. R. Gambari is supported by AIRC.",
year = "2014",
month = mar,
day = "14",
doi = "10.1039/c3dt52879k",
language = "English",
volume = "43",
pages = "3949--3957",
journal = "Dalton Transactions",
issn = "1477-9226",
publisher = "Royal Society of Chemistry",
number = "10",
}
