Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P. L. Lam; G. L. Lu; K. M. Hon; K. W. Lee; Cheuk Lam HO; X. Wang; J. C.O. Tang; K. H. Lam; R. S.M. Wong; S. H.L. Kok; Zhaoxiang BIAN; H. Li; K. K.H. Lee; R. Gambari; Chung Hin CHUI; Wai Yeung WONG

doi:10.1039/c3dt52879k

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P. L. Lam, G. L. Lu, K. M. Hon, K. W. Lee, Cheuk Lam HO, X. Wang, J. C.O. Tang, K. H. Lam, R. S.M. Wong, S. H.L. Kok, Zhaoxiang BIAN, H. Li^*, K. K.H. Lee, R. Gambari, Chung Hin CHUI, Wai Yeung WONG

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C₁, Ru-C₆, Ru-C₇ and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C₇ complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL^-1) and minimum bactericidal concentration (MBC, 25 μg mL^-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL^-1 and MBC = 100 μg mL^-1). The Ru-C₇ complex possessed much stronger antibacterial effects than the Ru-C₆ complex (MIC, 25 μg mL^-1, MBC, >100 μg mL^-1). Both Ru-C₆ and Ru-C₇ complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Original language	English
Pages (from-to)	3949-3957
Number of pages	9
Journal	Dalton Transactions
Volume	43
Issue number	10
DOIs	https://doi.org/10.1039/c3dt52879k
Publication status	Published - 14 Mar 2014

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Inorganic Chemistry

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Lam, P. L., Lu, G. L., Hon, K. M., Lee, K. W., HO, C. L., Wang, X., Tang, J. C. O., Lam, K. H., Wong, R. S. M., Kok, S. H. L., BIAN, Z., Li, H., Lee, K. K. H., Gambari, R., CHUI, C. H., & WONG, W. Y. (2014). Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus. Dalton Transactions, 43(10), 3949-3957. https://doi.org/10.1039/c3dt52879k

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title = "Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus",

abstract = "A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.",

author = "Lam, {P. L.} and Lu, {G. L.} and Hon, {K. M.} and Lee, {K. W.} and HO, {Cheuk Lam} and X. Wang and Tang, {J. C.O.} and Lam, {K. H.} and Wong, {R. S.M.} and Kok, {S. H.L.} and Zhaoxiang BIAN and H. Li and Lee, {K. K.H.} and R. Gambari and CHUI, {Chung Hin} and WONG, {Wai Yeung}",

year = "2014",

month = mar,

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doi = "10.1039/c3dt52879k",

language = "English",

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journal = "Dalton Transactions",

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AU - Lam, P. L.

AU - Lu, G. L.

AU - Hon, K. M.

AU - Lee, K. W.

AU - HO, Cheuk Lam

AU - Wang, X.

AU - Tang, J. C.O.

AU - Lam, K. H.

AU - Wong, R. S.M.

AU - Kok, S. H.L.

AU - BIAN, Zhaoxiang

AU - Li, H.

AU - Lee, K. K.H.

AU - Gambari, R.

AU - CHUI, Chung Hin

AU - WONG, Wai Yeung

PY - 2014/3/14

Y1 - 2014/3/14

N2 - A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

AB - A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

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VL - 43

SP - 3949

EP - 3957

JO - Dalton Transactions

JF - Dalton Transactions

IS - 10

ER -

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Abstract

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