Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P. L. Lam, G. L. Lu, K. M. Hon, K. W. Lee, Cheuk Lam HO, X. Wang, J. C.O. Tang, K. H. Lam, R. S.M. Wong, S. H.L. Kok, Zhaoxiang BIAN, H. Li*, K. K.H. Lee, R. Gambari, Chung Hin CHUI, Wai Yeung WONG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

A series of ruthenium(ii) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL-1) and minimum bactericidal concentration (MBC, 25 μg mL-1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL-1 and MBC = 100 μg mL-1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL-1, MBC, >100 μg mL-1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Original languageEnglish
Pages (from-to)3949-3957
Number of pages9
JournalDalton Transactions
Volume43
Issue number10
DOIs
Publication statusPublished - 14 Mar 2014

Scopus Subject Areas

  • Inorganic Chemistry

Fingerprint

Dive into the research topics of 'Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus'. Together they form a unique fingerprint.

Cite this