Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

Dik Lung Ma; Chun Wu; Sha Sha Cheng; Fu Wa Lee; Quan Bin Han; Chung Hang Leung

doi:10.3390/ijms20020341

Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

Dik Lung Ma^*, Chun Wu, Sha Sha Cheng, Fu Wa Lee, Quan Bin Han, Chung Hang Leung^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

25 Citations (Scopus)

Abstract

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

Original language	English
Article number	341
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	2
DOIs	https://doi.org/10.3390/ijms20020341
Publication status	Published - 2 Jan 2019

Scopus Subject Areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

User-Defined Keywords

Cancer therapy
Cytotoxicity
Natural product
Transition metal complex

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms20020341

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title = "Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies",

abstract = "Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.",

keywords = "Cancer therapy, Cytotoxicity, Natural product, Transition metal complex",

author = "Ma, {Dik Lung} and Chun Wu and Cheng, {Sha Sha} and Lee, {Fu Wa} and Han, {Quan Bin} and Leung, {Chung Hang}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007 and FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121 and 21775131), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/17-18/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), the Science and Technology Development Fund, Macao SAR (0072/2018/A2), and the University of Macau (MYRG2018-00187-ICMS and MYRG2016-00151-ICMS-QRCM). Publisher copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jan,

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doi = "10.3390/ijms20020341",

language = "English",

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journal = "International Journal of Molecular Sciences",

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AU - Ma, Dik Lung

AU - Wu, Chun

AU - Cheng, Sha Sha

AU - Lee, Fu Wa

AU - Han, Quan Bin

AU - Leung, Chung Hang

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007 and FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121 and 21775131), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/17-18/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), the Science and Technology Development Fund, Macao SAR (0072/2018/A2), and the University of Macau (MYRG2018-00187-ICMS and MYRG2016-00151-ICMS-QRCM). Publisher copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2019/1/2

Y1 - 2019/1/2

N2 - Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

AB - Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.

KW - Cancer therapy

KW - Cytotoxicity

KW - Natural product

KW - Transition metal complex

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M3 - Review article

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Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

Abstract

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UN SDGs

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