@article{159afa2705a54f51aabbf842cb3b3857,
title = "Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies",
abstract = "Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.",
keywords = "Cancer therapy, Cytotoxicity, Natural product, Transition metal complex",
author = "Ma, {Dik Lung} and Chun Wu and Cheng, {Sha Sha} and Lee, {Fu Wa} and Han, {Quan Bin} and Leung, {Chung Hang}",
note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007 and FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121 and 21775131), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/17-18/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), the Science and Technology Development Fund, Macao SAR (0072/2018/A2), and the University of Macau (MYRG2018-00187-ICMS and MYRG2016-00151-ICMS-QRCM). Publisher copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = jan,
day = "2",
doi = "10.3390/ijms20020341",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI",
number = "2",
}
