Development of an Antiviral Screening Protocol: One-Stone-Two-Birds

Emily Rumschlag-Booms*, Hongjie Zhang, Djaja Doel Soejarto, Harry H.S. Fong, Lijun Rong

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

23 Citations (Scopus)


As prophylactic therapies and vaccines against viral infections continue to improve, drug resistant strains are continuing to arise; therefore it is imperative to develop new therapeutics against these diseases. For highly pathogenic viruses, such as Ebola and H5N1 influenza virus, the need for antivirals is even more urgent due to limited therapeutics against these viruses. Furthermore, the high pathogenicity of such viruses often makes it difficult to work with such agents. In this report, we describe a protocol called “One-stone-two-birds” which provides a safe and efficient screening system to identify anti-flu (entry) and anti-HIV (replication) activities. Using plant extracts as an example, we demonstrate the utility of this protocol in antiviral screening.
Original languageEnglish
Pages (from-to)008-010
Number of pages3
JournalJournal of Antivirals and Antiretrovirals
Issue number1
Publication statusPublished - Jan 2011

User-Defined Keywords

  • Antiviral
  • Influenza
  • HIV
  • Ebola
  • Plant extract
  • Screening


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