Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung; Roberto Gambari; Yi Xin Chen; Chor Hing Cheng; Zhaoxiang BIAN; Albert Sun Chi Chan; Johnny Cheuk On Tang; Polly Hang Mei Leung; Chung Hin CHUI; Kim Hung Lam

doi:10.1007/s00044-014-1217-4

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung
, Roberto Gambari
, Yi Xin Chen
, Chor Hing Cheng
, Zhaoxiang BIAN
, Albert Sun Chi Chan
, Johnny Cheuk On Tang
, Polly Hang Mei Leung
, Chung Hin CHUI^*
, Kim Hung Lam

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

12 Citations (Scopus)

Abstract

A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

Original language	English
Pages (from-to)	1568-1577
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s00044-014-1217-4
Publication status	Published - Apr 2015

User-Defined Keywords

8-Hydroxyquinoline
A549 cells
Antimicrobial
Aspergillus niger

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10.1007/s00044-014-1217-4

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title = "Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities",

abstract = "A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.",

keywords = "8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger",

author = "Chung, \{Po Yee\} and Roberto Gambari and Chen, \{Yi Xin\} and Cheng, \{Chor Hing\} and Zhaoxiang BIAN and Chan, \{Albert Sun Chi\} and Tang, \{Johnny Cheuk On\} and Leung, \{Polly Hang Mei\} and CHUI, \{Chung Hin\} and Lam, \{Kim Hung\}",

note = "Publisher Copyright: {\textcopyright} 2014 Springer Science+Business Media New York.",

year = "2015",

month = apr,

doi = "10.1007/s00044-014-1217-4",

language = "English",

volume = "24",

pages = "1568--1577",

journal = "Medicinal Chemistry Research",

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TY - JOUR

T1 - Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

AU - Chung, Po Yee

AU - Gambari, Roberto

AU - Chen, Yi Xin

AU - Cheng, Chor Hing

AU - BIAN, Zhaoxiang

AU - Chan, Albert Sun Chi

AU - Tang, Johnny Cheuk On

AU - Leung, Polly Hang Mei

AU - CHUI, Chung Hin

AU - Lam, Kim Hung

PY - 2015/4

Y1 - 2015/4

N2 - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

AB - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

KW - 8-Hydroxyquinoline

KW - A549 cells

KW - Antimicrobial

KW - Aspergillus niger

UR - https://www.scopus.com/pages/publications/84943015111

U2 - 10.1007/s00044-014-1217-4

DO - 10.1007/s00044-014-1217-4

M3 - Journal article

AN - SCOPUS:84943015111

SN - 1054-2523

VL - 24

SP - 1568

EP - 1577

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 4

ER -

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Abstract

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