Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung; Roberto Gambari; Yi Xin Chen; Chor Hing Cheng; Zhaoxiang BIAN; Albert Sun Chi Chan; Johnny Cheuk On Tang; Polly Hang Mei Leung; Chung Hin CHUI; Kim Hung Lam

doi:10.1007/s00044-014-1217-4

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung, Roberto Gambari, Yi Xin Chen, Chor Hing Cheng, Zhaoxiang BIAN, Albert Sun Chi Chan, Johnny Cheuk On Tang, Polly Hang Mei Leung, Chung Hin CHUI^*, Kim Hung Lam

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

12 Citations (Scopus)

Abstract

A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

Original language	English
Pages (from-to)	1568-1577
Number of pages	10
Journal	Medicinal Chemistry Research
Volume	24
Issue number	4
DOIs	https://doi.org/10.1007/s00044-014-1217-4
Publication status	Published - Apr 2015

Scopus Subject Areas

Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

User-Defined Keywords

8-Hydroxyquinoline
A549 cells
Antimicrobial
Aspergillus niger

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10.1007/s00044-014-1217-4

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title = "Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities",

abstract = "A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.",

keywords = "8-Hydroxyquinoline, A549 cells, Antimicrobial, Aspergillus niger",

author = "Chung, {Po Yee} and Roberto Gambari and Chen, {Yi Xin} and Cheng, {Chor Hing} and Zhaoxiang BIAN and Chan, {Albert Sun Chi} and Tang, {Johnny Cheuk On} and Leung, {Polly Hang Mei} and CHUI, {Chung Hin} and Lam, {Kim Hung}",

note = "Publisher Copyright: {\textcopyright} 2014 Springer Science+Business Media New York.",

year = "2015",

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doi = "10.1007/s00044-014-1217-4",

language = "English",

volume = "24",

pages = "1568--1577",

journal = "Medicinal Chemistry Research",

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TY - JOUR

T1 - Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

AU - Chung, Po Yee

AU - Gambari, Roberto

AU - Chen, Yi Xin

AU - Cheng, Chor Hing

AU - BIAN, Zhaoxiang

AU - Chan, Albert Sun Chi

AU - Tang, Johnny Cheuk On

AU - Leung, Polly Hang Mei

AU - CHUI, Chung Hin

AU - Lam, Kim Hung

PY - 2015/4

Y1 - 2015/4

N2 - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

AB - A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

KW - 8-Hydroxyquinoline

KW - A549 cells

KW - Antimicrobial

KW - Aspergillus niger

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U2 - 10.1007/s00044-014-1217-4

DO - 10.1007/s00044-014-1217-4

M3 - Journal article

AN - SCOPUS:84943015111

SN - 1054-2523

VL - 24

SP - 1568

EP - 1577

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

IS - 4

ER -

Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Abstract

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