Development of 8-benzyloxy-substituted quinoline ethers and evaluation of their antimicrobial activities

Po Yee Chung, Roberto Gambari, Yi Xin Chen, Chor Hing Cheng, Zhaoxiang BIAN, Albert Sun Chi Chan, Johnny Cheuk On Tang, Polly Hang Mei Leung, Chung Hin CHUI*, Kim Hung Lam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

A series of 8-benzyloxy-substituted quinoline ethers (2a-n) compounds were synthesized. All synthesized compounds were screened in vitro for their preliminary antimicrobial activities against two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli), two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), and a fungal species (Aspergillus niger). Among all synthesized compounds, compound 2e showed a significant growth inhibitory activity with MIC value 3.125 μg/mL which was comparable to 8-hydroxyquinoline (2.5 μg/mL) and terbinafine (1.25 μg/mL) against A. niger.

Original languageEnglish
Pages (from-to)1568-1577
Number of pages10
JournalMedicinal Chemistry Research
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 2015

Scopus Subject Areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

User-Defined Keywords

  • 8-Hydroxyquinoline
  • A549 cells
  • Antimicrobial
  • Aspergillus niger

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