Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

Wai Tang Ma; Wan Chan; Klaus Steinbach; Zongwei CAI

doi:10.1007/s00216-006-1067-0

Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

Wai Tang Ma, Wan Chan, Klaus Steinbach, Zongwei CAI^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

6 Citations (Scopus)

Abstract

A method involving solid-phase extraction (SPE) and reversed-phase liquid chromatography-mass spectrometry (LC-MS) has been developed for determination, in groundwater, of nitrobenzoic acids associated with 2,4,6-trinitrotoluene production. Pre-concentration on a co-polymer-based SPE cartridge enabled quantitative extraction of the analytes from water. Investigation of negative ion electrospray and atmospheric-pressure chemical ionization mass spectrometry indicated the sensitivity of APCI was more than twice that of ESI. An ¹⁵N-labeled internal standard was used to achieve more accurate quantitation and mass assignment. Recovery was better than 80% when 10 mL water was extracted with the SPE cartridge. Combination of SPE with LC-MS analysis resulted in method detection limits of less than 5 μg L^-1. The method has been used for analysis of groundwater samples collected from a site of a former ammunition plant. Contamination with nitrobenzoic acids was determined at μg L^-1 levels.

Original language	English
Pages (from-to)	2219-2225
Number of pages	7
Journal	Analytical and Bioanalytical Chemistry
Volume	387
Issue number	6
DOIs	https://doi.org/10.1007/s00216-006-1067-0
Publication status	Published - Mar 2007

Scopus Subject Areas

Analytical Chemistry
Biochemistry

User-Defined Keywords

Groundwater
Nitrobenzoic acids
Solid-phase extraction
Trinitrotoluene

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10.1007/s00216-006-1067-0

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title = "Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry",

abstract = "A method involving solid-phase extraction (SPE) and reversed-phase liquid chromatography-mass spectrometry (LC-MS) has been developed for determination, in groundwater, of nitrobenzoic acids associated with 2,4,6-trinitrotoluene production. Pre-concentration on a co-polymer-based SPE cartridge enabled quantitative extraction of the analytes from water. Investigation of negative ion electrospray and atmospheric-pressure chemical ionization mass spectrometry indicated the sensitivity of APCI was more than twice that of ESI. An 15N-labeled internal standard was used to achieve more accurate quantitation and mass assignment. Recovery was better than 80% when 10 mL water was extracted with the SPE cartridge. Combination of SPE with LC-MS analysis resulted in method detection limits of less than 5 μg L-1. The method has been used for analysis of groundwater samples collected from a site of a former ammunition plant. Contamination with nitrobenzoic acids was determined at μg L-1 levels.",

keywords = "Groundwater, Nitrobenzoic acids, Solid-phase extraction, Trinitrotoluene",

author = "Ma, {Wai Tang} and Wan Chan and Klaus Steinbach and Zongwei CAI",

note = "Funding Information: Acknowledgement The work described in this paper was supported by a grant from the Germany Academic Exchange Service and the Research Grant Council (RGC) of the Hong Kong Joint Research Scheme (GER/ JRS/0102/01). The authors are grateful for financial support in the form of a Faculty Research Grant (FRG/02-03/II-36) from Hong Kong Baptist University and an RGC-CERG grant (HKBU2017/02P) from RGC.",

year = "2007",

month = mar,

doi = "10.1007/s00216-006-1067-0",

language = "English",

volume = "387",

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journal = "Analytical and Bioanalytical Chemistry",

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AU - Ma, Wai Tang

AU - Chan, Wan

AU - Steinbach, Klaus

AU - CAI, Zongwei

N1 - Funding Information: Acknowledgement The work described in this paper was supported by a grant from the Germany Academic Exchange Service and the Research Grant Council (RGC) of the Hong Kong Joint Research Scheme (GER/ JRS/0102/01). The authors are grateful for financial support in the form of a Faculty Research Grant (FRG/02-03/II-36) from Hong Kong Baptist University and an RGC-CERG grant (HKBU2017/02P) from RGC.

PY - 2007/3

Y1 - 2007/3

N2 - A method involving solid-phase extraction (SPE) and reversed-phase liquid chromatography-mass spectrometry (LC-MS) has been developed for determination, in groundwater, of nitrobenzoic acids associated with 2,4,6-trinitrotoluene production. Pre-concentration on a co-polymer-based SPE cartridge enabled quantitative extraction of the analytes from water. Investigation of negative ion electrospray and atmospheric-pressure chemical ionization mass spectrometry indicated the sensitivity of APCI was more than twice that of ESI. An 15N-labeled internal standard was used to achieve more accurate quantitation and mass assignment. Recovery was better than 80% when 10 mL water was extracted with the SPE cartridge. Combination of SPE with LC-MS analysis resulted in method detection limits of less than 5 μg L-1. The method has been used for analysis of groundwater samples collected from a site of a former ammunition plant. Contamination with nitrobenzoic acids was determined at μg L-1 levels.

AB - A method involving solid-phase extraction (SPE) and reversed-phase liquid chromatography-mass spectrometry (LC-MS) has been developed for determination, in groundwater, of nitrobenzoic acids associated with 2,4,6-trinitrotoluene production. Pre-concentration on a co-polymer-based SPE cartridge enabled quantitative extraction of the analytes from water. Investigation of negative ion electrospray and atmospheric-pressure chemical ionization mass spectrometry indicated the sensitivity of APCI was more than twice that of ESI. An 15N-labeled internal standard was used to achieve more accurate quantitation and mass assignment. Recovery was better than 80% when 10 mL water was extracted with the SPE cartridge. Combination of SPE with LC-MS analysis resulted in method detection limits of less than 5 μg L-1. The method has been used for analysis of groundwater samples collected from a site of a former ammunition plant. Contamination with nitrobenzoic acids was determined at μg L-1 levels.

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Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

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