Determination of five nitrobenzoic acids in groundwater by solid-phase extraction and liquid chromatography-mass spectrometry

Wai Tang Ma, Wan Chan, Klaus Steinbach, Zongwei CAI*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

A method involving solid-phase extraction (SPE) and reversed-phase liquid chromatography-mass spectrometry (LC-MS) has been developed for determination, in groundwater, of nitrobenzoic acids associated with 2,4,6-trinitrotoluene production. Pre-concentration on a co-polymer-based SPE cartridge enabled quantitative extraction of the analytes from water. Investigation of negative ion electrospray and atmospheric-pressure chemical ionization mass spectrometry indicated the sensitivity of APCI was more than twice that of ESI. An 15N-labeled internal standard was used to achieve more accurate quantitation and mass assignment. Recovery was better than 80% when 10 mL water was extracted with the SPE cartridge. Combination of SPE with LC-MS analysis resulted in method detection limits of less than 5 μg L-1. The method has been used for analysis of groundwater samples collected from a site of a former ammunition plant. Contamination with nitrobenzoic acids was determined at μg L-1 levels.

Original languageEnglish
Pages (from-to)2219-2225
Number of pages7
JournalAnalytical and Bioanalytical Chemistry
Volume387
Issue number6
DOIs
Publication statusPublished - Mar 2007

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry

User-Defined Keywords

  • Groundwater
  • Nitrobenzoic acids
  • Solid-phase extraction
  • Trinitrotoluene

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