Determination of endogenous trace metal contents in various mouse brain regions after prolonged oral administration of aluminum chloride

M. S. Yang*, H. F. Wong, Kin Lam YUNG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Aluminum (Al) has been said to associate with the Alzheimer’s-like neurodegeneration in humans. One of the proposed mechanisms for the action of Al is that excess Al might interfere with trace metal metabolism. In this study, the levels of Ca, Mg, Cu, and Zn in blood, liver, and different regions of the brain (separated into the cortex, hippocampus, cerebellum, and brainstem) were measured in mice after daily oral administration of AlCl3 (100 mg/kg body weight) for 2 mo. It was found that upon prolonged oral admin3 istration of Al, serum Al level was elevated significantly. There was no marked change in serum Ca, Mg, Zn, or Cu content. In the liver, Al content was not increased but there was a significant elevation in Cu and Zn content compared to control animals, probably due to the prolonged administration of the acidic salt solution. In brain, there was a significant twofold increase in Al in the hippocampus and a significant decrease in Al in the cortex. In addition to regional changes in Al content, Zn content in the hippocampus and increased Cu content in the hippocampus, cortex, and brainstem were significantly reduced. Data demonstrated that Al could alter Zn and Cu homeostasis in selected brain regions. The possible relation between Al and neuronal cell injury was discussed.

Original languageEnglish
Pages (from-to)445-453
Number of pages9
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume55
Issue number6
DOIs
Publication statusPublished - Dec 1998

Scopus Subject Areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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