TY - JOUR
T1 - Determination and regulation of hepatotoxic pyrrolizidine alkaloids in food
T2 - A critical review of recent research
AU - Ma, Chuanhui
AU - Liu, Yang
AU - Zhu, Lin
AU - Ji, Hong
AU - Song, Xun
AU - Guo, Hui
AU - Yi, Tao
N1 - Funding Information:
The present study was supported by National Natural Science Foundation of China (Grant no. 81603381).
Publisher copyright:
© 2018 Published by Elsevier Ltd.
PY - 2018/9
Y1 - 2018/9
N2 - Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins affecting livestock, wildlife, and humans. To date, over 10,000 PAs poisoning cases have been reported worldwide. In recent years, many articles have reported the detection of PAs in various foods, including honey, milk, meat, eggs, tea and salad. This review summarized the contamination of PAs in foods, state of the art detection methods and regulations by different countries and authorities, hoping to propose effective solutions to minimize the consumption of PAs in food.
AB - Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins affecting livestock, wildlife, and humans. To date, over 10,000 PAs poisoning cases have been reported worldwide. In recent years, many articles have reported the detection of PAs in various foods, including honey, milk, meat, eggs, tea and salad. This review summarized the contamination of PAs in foods, state of the art detection methods and regulations by different countries and authorities, hoping to propose effective solutions to minimize the consumption of PAs in food.
KW - Determination
KW - Food
KW - Pyrrolizidine alkaloids (PAs)
KW - Regulation
UR - http://www.scopus.com/inward/record.url?scp=85047824398&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2018.05.037
DO - 10.1016/j.fct.2018.05.037
M3 - Journal article
C2 - 29772268
AN - SCOPUS:85047824398
SN - 0278-6915
VL - 119
SP - 50
EP - 60
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
ER -