@article{6c0cb28152b14e81b49843515443d617,
title = "Detection of base excision repair enzyme activity using a luminescent g-quadruplex selective switch-on probe",
abstract = "We report herein a simple and convenient luminescent assay for detection of base excision repair enzyme activity using an Ir(III) complex as a G-quadruplex selective probe. Using uracil-DNA glycosylase (UDG) as a model enzyme, the assay achieved high sensitivity and selectivity for UDG over other tested enzymes. The utility of the assay for screening potential UDG inhibitors was also demonstrated.",
author = "Leung, {Ka Ho} and He, {Hong Zhang} and Ma, {Victor Pui Yan} and Zhong, {Hai Jing} and Chan, {Daniel Shiu Hin} and Jun Zhou and Mergny, {Jean Louis} and Leung, {Chung Hang} and Ma, {Dik Lung}",
note = "This work was supported by Hong Kong Baptist University (FRG2/11-12/009), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811 and HKBU/204612), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (001/2012/A) and the University of Macau (MYRG091(Y2-L2)-ICMS12-LCH and MYRG121(Y2-L2)-ICMS12-LCH).",
year = "2013",
month = may,
day = "28",
doi = "10.1039/c3cc41129j",
language = "English",
volume = "49",
pages = "5630--5632",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "50",
}