Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs

Yahui Guo; Yao Zhang; Renjun Pei; Yuliang Cheng; Yunfei Xie; Hang Yu; Weirong Yao; Hung Wing Li; He Qian

doi:10.1016/j.snb.2018.10.101

Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs

Yahui Guo, Yao Zhang, Renjun Pei, Yuliang Cheng, Yunfei Xie, Hang Yu, Weirong Yao, Hung Wing Li^*, He Qian

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

21 Citations (Scopus)

Abstract

In this work, a new phenomenon was found that the insertion of guanine (G) bases into the cytosine (C)-rich DNA could endow enhanced fluorescence intensity of DNA-templated silver nanoclusters (DNA-AgNCs). This could be another important finding after Yeh's report that DNA-AgNCs can be greatly enhanced when placed in proximity to G-rich bases and, a supplementary proof for the understanding of G&C roles in the synthesis of DNA-AgNCs. A sequence (C₆G₅G₆) was selected for the synthesis of DNA-AgNCs of quantum yield 28%. The AgNCs were employed as a visual and facile probe for the sensitive detection of captopril in antihypertensive health food. This detection strategy showed good linear response to captopril with applicability in complex matrices of real samples.

Original language	English
Pages (from-to)	493-498
Number of pages	6
Journal	Sensors and Actuators B: Chemical
Volume	281
DOIs	https://doi.org/10.1016/j.snb.2018.10.101
Publication status	Published - 15 Feb 2019

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

User-Defined Keywords

Food adulteration assay
G-insertion enhanced fluorescence
Silver nanoclusters
Visual probe

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10.1016/j.snb.2018.10.101

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title = "Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs",

abstract = "In this work, a new phenomenon was found that the insertion of guanine (G) bases into the cytosine (C)-rich DNA could endow enhanced fluorescence intensity of DNA-templated silver nanoclusters (DNA-AgNCs). This could be another important finding after Yeh's report that DNA-AgNCs can be greatly enhanced when placed in proximity to G-rich bases and, a supplementary proof for the understanding of G&C roles in the synthesis of DNA-AgNCs. A sequence (C6G5G6) was selected for the synthesis of DNA-AgNCs of quantum yield 28%. The AgNCs were employed as a visual and facile probe for the sensitive detection of captopril in antihypertensive health food. This detection strategy showed good linear response to captopril with applicability in complex matrices of real samples.",

keywords = "Food adulteration assay, G-insertion enhanced fluorescence, Silver nanoclusters, Visual probe",

author = "Yahui Guo and Yao Zhang and Renjun Pei and Yuliang Cheng and Yunfei Xie and Hang Yu and Weirong Yao and Li, {Hung Wing} and He Qian",

note = "Funding Information: This work is ﬁnancially supported by the National Science Foundation of China (No. 31601552 ), the Key R&D Plan of Jiangsu Province (No. BE2016664 ), Jiangsu Agriculture Science and Technology Innovation Fund (No. CX(16)1028 ), National Key R&D Program of China ( 2017YFC1601700 ), and the “HongKong Scholar” program . ",

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doi = "10.1016/j.snb.2018.10.101",

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T1 - Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs

AU - Guo, Yahui

AU - Zhang, Yao

AU - Pei, Renjun

AU - Cheng, Yuliang

AU - Xie, Yunfei

AU - Yu, Hang

AU - Yao, Weirong

AU - Li, Hung Wing

AU - Qian, He

N1 - Funding Information: This work is ﬁnancially supported by the National Science Foundation of China (No. 31601552 ), the Key R&D Plan of Jiangsu Province (No. BE2016664 ), Jiangsu Agriculture Science and Technology Innovation Fund (No. CX(16)1028 ), National Key R&D Program of China ( 2017YFC1601700 ), and the “HongKong Scholar” program .

PY - 2019/2/15

Y1 - 2019/2/15

N2 - In this work, a new phenomenon was found that the insertion of guanine (G) bases into the cytosine (C)-rich DNA could endow enhanced fluorescence intensity of DNA-templated silver nanoclusters (DNA-AgNCs). This could be another important finding after Yeh's report that DNA-AgNCs can be greatly enhanced when placed in proximity to G-rich bases and, a supplementary proof for the understanding of G&C roles in the synthesis of DNA-AgNCs. A sequence (C6G5G6) was selected for the synthesis of DNA-AgNCs of quantum yield 28%. The AgNCs were employed as a visual and facile probe for the sensitive detection of captopril in antihypertensive health food. This detection strategy showed good linear response to captopril with applicability in complex matrices of real samples.

AB - In this work, a new phenomenon was found that the insertion of guanine (G) bases into the cytosine (C)-rich DNA could endow enhanced fluorescence intensity of DNA-templated silver nanoclusters (DNA-AgNCs). This could be another important finding after Yeh's report that DNA-AgNCs can be greatly enhanced when placed in proximity to G-rich bases and, a supplementary proof for the understanding of G&C roles in the synthesis of DNA-AgNCs. A sequence (C6G5G6) was selected for the synthesis of DNA-AgNCs of quantum yield 28%. The AgNCs were employed as a visual and facile probe for the sensitive detection of captopril in antihypertensive health food. This detection strategy showed good linear response to captopril with applicability in complex matrices of real samples.

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KW - G-insertion enhanced fluorescence

KW - Silver nanoclusters

KW - Visual probe

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DO - 10.1016/j.snb.2018.10.101

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SN - 0925-4005

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JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

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Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs

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