Detecting the adulteration of antihypertensive health food using G-insertion enhanced fluorescent DNA-AgNCs

Yahui Guo, Yao Zhang, Renjun Pei, Yuliang Cheng, Yunfei Xie, Hang Yu, Weirong Yao, Hung Wing LI*, He Qian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

In this work, a new phenomenon was found that the insertion of guanine (G) bases into the cytosine (C)-rich DNA could endow enhanced fluorescence intensity of DNA-templated silver nanoclusters (DNA-AgNCs). This could be another important finding after Yeh's report that DNA-AgNCs can be greatly enhanced when placed in proximity to G-rich bases and, a supplementary proof for the understanding of G&C roles in the synthesis of DNA-AgNCs. A sequence (C6G5G6) was selected for the synthesis of DNA-AgNCs of quantum yield 28%. The AgNCs were employed as a visual and facile probe for the sensitive detection of captopril in antihypertensive health food. This detection strategy showed good linear response to captopril with applicability in complex matrices of real samples.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume281
DOIs
Publication statusPublished - 15 Feb 2019

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

User-Defined Keywords

  • Food adulteration assay
  • G-insertion enhanced fluorescence
  • Silver nanoclusters
  • Visual probe

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