Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren's syndrome

Lin Xiao, Tzi Bun Ng, Yi-Bin Feng, Tong Yao, Jack Ho Wong, Ren-Min Yao, Lei Li, Fei-Zhi Mo, Yin Xiao, Pang-Chui Shaw, Ze-Min Li, Stephen Cho Wing Sze*, Kalin Yanbo Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to investigate the mechanism of Dendrobium candidum extract in promoting expression of aquaporin-5 for treatment of Sjögren's syndrome (SS). Sixteen patients with SS suffered from deficient secretion of saliva due to an autoimmune destruction of salivary glands leading to dry mouth symptoms (xerostomia). However, glandular dysfunction also occurred without destruction. Based upon its abnormal distribution in SS salivary glands, a potential role of the water channel protein aquaporin-5 (AQP-5) in the pathogenesis of SS was proposed. After oral administration of D. candidum extracted liquid (DCEL) for 1 week, saliva and salivary gland biopsies from labial glands of patients were collected and examined by employing immunoreactivity and immunohistochemistry techniques. Results showed that salivary secretion increased by about 65% in patients treated with DCEL as compared with the control group. Higher labeling indices (percentage of acinus area immunoreactive for AQP-5) in the biopsies were found in SS patients who had taken DCEL. This study demonstrated that D. candidum would regulate the expression of AQP-5 in labial glands of SS patients and thereby promoted secretion of saliva to improve dry mouth symptoms.
Original languageEnglish
Pages (from-to)194-198
Number of pages5
JournalPhytomedicine
Volume18
Issue number2-3
DOIs
Publication statusPublished - 15 Jan 2011
Externally publishedYes

Scopus Subject Areas

  • Medicine(all)

User-Defined Keywords

  • Dendrobium candidum
  • Mechanisms
  • Aquaporin-5 (AQP-5)
  • Sjögren's syndrome (SS)
  • Labial gland
  • Herb medicine

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