DeepMoIC: multi-omics data integration via deep graph convolutional networks for cancer subtype classification

Background: Achieving precise cancer subtype classification is imperative for effective prognosis and treatment. Multi-omics studies, encompassing diverse data modalities, have emerged as powerful tools for unraveling the complexities of cancer. However, owing to the intricacies of biological data, multi-omics datasets generally show variations in data types, scales, and distributions. These intractable problems lead to challenges in exploring intact representations from heterogeneous data, which often result in inaccuracies in multi-omics information analysis. Results: To address the challenges of multi-omics research, our approach DeepMoIC presents a novel framework derived from deep Graph Convolutional Network (GCN). Leveraging autoencoder modules, DeepMoIC extracts compact representations from omics data and incorporates a patient similarity network through the similarity network fusion algorithm. To handle non-Euclidean data and explore high-order omics information effectively, we design a Deep GCN module with two strategies: residual connection and identity mapping. With extracted higher-order representations, our approach consistently outperforms state-of-the-art models on a pan-cancer dataset and 3 cancer subtype datasets. Conclusion: The introduction of Deep GCN shows encouraging performance in terms of supervised multi-omics feature learning, offering promising insights for precision medicine in cancer research. DeepMoIC can potentially be an important tool in the field of cancer subtype classification because of its capacity to handle complex multi-omics data and produce reliable classification findings.