Deciphering the molecular genetic basis of NPC through functional approaches

Hong Lok Lung, Arthur Kwok Leung Cheung, Josephine Mun Yee Ko, Yue Cheng, Eric J. Stanbridge, Maria Li Lung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


The identification of cancer genes in sporadic cancers has been recognized as a major challenge in the field. It is clear that deletion mapping, genomic sequencing, comparative genomic hybridization, or global gene expression profiling alone would not have easily identified candidate tumor suppressor genes (TSGs) from the huge array of lost regions or genes observed in nasopharyngeal carcinoma (NPC). In addition, the epigenetically silenced genes would not have been recognized by the mapping of deleted regions. In this review, we describe how functional approaches using monochromosome transfer may be used to circumvent the above problems and identify TSGs in NPC. A few examples of selected NPC TSGs and their functional roles are reviewed. They regulate a variety of gene functions including cell growth and proliferation, adhesion, migration, invasion, epithelial-mesenchymal transition, metastasis, and angiogenesis. These studies show the advantages of using functional approaches for identification of TSGs.

Original languageEnglish
Pages (from-to)87-95
Number of pages9
JournalSeminars in Cancer Biology
Issue number2
Publication statusPublished - Apr 2012

Scopus Subject Areas

  • Cancer Research

User-Defined Keywords

  • Microcell hybrid
  • Microcell-mediated chromosome transfer
  • Nasopharyngeal carcinoma
  • Tumor segregant
  • Tumor suppressor gene


Dive into the research topics of 'Deciphering the molecular genetic basis of NPC through functional approaches'. Together they form a unique fingerprint.

Cite this