Daily energy expenditure through the human life course

Herman Pontzer; Yosuke Yamada; Hiroyuki Sagayama; Philip N. Ainslie; Lene F. Andersen; Liam J. Anderson; Lenore Arab; Issaad Baddou; Kweku Bedu-Addo; Ellen E. Blaak; Stephane Blanc; Alberto G. Bonomi; Carlijn V. C. Bouten; Pascal Bovet; Maciej S. Buchowski; Nancy F. Butte; Stefan G. Camps; Graeme L. Close; Jamie A. Cooper; Richard Cooper; Sai Krupa Das; Lara R. Dugas; Ulf Ekelund; Sonja Entringer; Terrence Forrester; Barry W. Fudge; Annelies H Goris; Michael Gurven; Catherine Hambly; Asmaa El Hamdouchi; Marjije B. Hoos; Sumei Hu; Noorjehan Joonas; Annemiek M. Joosen; Peter Katzmarzyk; Kitty P. Kempen; Misaka Kimura; William E. Kraus; Robert F. Kushner; Estelle V. Lambert; William R. Leonard; Nader Lessan; Corby Martin; Anine C. Medin; Erwin P. Meijer; James C. Morehen; James P. Morton; Marian L. Neuhouser; Teresa A. Nicklas; Robert M. Ojiambo; Kirsi H. Pietiläinen; Yannis P. Pitsiladis; Jacob Plange-Rhule; Guy Plasqui; Ross L. Prentice; Roberto A. Rabinovich; Susan B. Racette; David A. Raichlen; Eric Ravussin; Rebecca M. Reynolds; Susan B. Roberts; Albertine J. Schuit; Anders M. Sjödin; Eric Stice; Samuel S. Urlacher; Giulio Valenti; Ludo M. Van Etten; Edgar A Van Mil; Jonathan C. K. Wells; George Wilson; Brian M. Wood; Jack Yanovski; Tsukasa Yoshida; Xueying Zhang; Alexia J. Murphy-Alford; Cornelia Loechl; Amy H. Luke; Jennifer Rood; Dale A. Schoeller; Klaas R. Westerterp; William W. Wong; John R. Speakman; IAEA DLW Database Consortium

doi:10.1126/science.abe5017

Daily energy expenditure through the human life course

Herman Pontzer^*
, Yosuke Yamada^*
, Hiroyuki Sagayama^*
, Philip N. Ainslie
, Lene F. Andersen
, Liam J. Anderson
, Lenore Arab
, Issaad Baddou
, Kweku Bedu-Addo
, Ellen E. Blaak
, Stephane Blanc
, Alberto G. Bonomi
, Carlijn V. C. Bouten
, Pascal Bovet
, Maciej S. Buchowski
, Nancy F. Butte
, Stefan G. Camps
, Graeme L. Close
, Jamie A. Cooper
, Richard Cooper

Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marjije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk, Kitty P. Kempen, Misaka Kimura, William E. Kraus, Robert F. Kushner, Estelle V. Lambert, William R. Leonard, Nader Lessan, Corby Martin, Anine C. Medin, Erwin P. Meijer, James C. Morehen, James P. Morton, Marian L. Neuhouser, Teresa A. Nicklas, Robert M. Ojiambo, Kirsi H. Pietiläinen, Yannis P. Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L. Prentice, Roberto A. Rabinovich, Susan B. Racette, David A. Raichlen, Eric Ravussin, Rebecca M. Reynolds, Susan B. Roberts, Albertine J. Schuit, Anders M. Sjödin, Eric Stice, Samuel S. Urlacher, Giulio Valenti, Ludo M. Van Etten, Edgar A Van Mil, Jonathan C. K. Wells, George Wilson, Brian M. Wood, Jack Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke^*, Jennifer Rood^*, Dale A. Schoeller^*, Klaas R. Westerterp^*, William W. Wong^*, John R. Speakman^*, IAEA DLW Database Consortium

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

420 Citations (Scopus)

Abstract

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Original language	English
Pages (from-to)	808-812
Number of pages	5
Journal	Science
Volume	373
Issue number	6556
DOIs	https://doi.org/10.1126/science.abe5017
Publication status	Published - 13 Aug 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/science.abe5017

Cite this

Pontzer, H., Yamada, Y., Sagayama, H., Ainslie, P. N., Andersen, L. F., Anderson, L. J., Arab, L., Baddou, I., Bedu-Addo, K., Blaak, E. E., Blanc, S., Bonomi, A. G., Bouten, C. V. C., Bovet, P., Buchowski, M. S., Butte, N. F., Camps, S. G., Close, G. L., Cooper, J. A., ... IAEA DLW Database Consortium (2021). Daily energy expenditure through the human life course. Science, 373(6556), 808-812. https://doi.org/10.1126/science.abe5017

@article{286e7c6bf3dc46e9b29e7c369ecfe5bf,

title = "Daily energy expenditure through the human life course",

abstract = "Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to \textasciitilde{}50\% above adult values at \textasciitilde{}1 year; declines slowly to adult levels by \textasciitilde{}20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.",

author = "Herman Pontzer and Yosuke Yamada and Hiroyuki Sagayama and Ainslie, \{Philip N.\} and Andersen, \{Lene F.\} and Anderson, \{Liam J.\} and Lenore Arab and Issaad Baddou and Kweku Bedu-Addo and Blaak, \{Ellen E.\} and Stephane Blanc and Bonomi, \{Alberto G.\} and Bouten, \{Carlijn V. C.\} and Pascal Bovet and Buchowski, \{Maciej S.\} and Butte, \{Nancy F.\} and Camps, \{Stefan G.\} and Close, \{Graeme L.\} and Cooper, \{Jamie A.\} and Richard Cooper and Das, \{Sai Krupa\} and Dugas, \{Lara R.\} and Ulf Ekelund and Sonja Entringer and Terrence Forrester and Fudge, \{Barry W.\} and Goris, \{Annelies H\} and Michael Gurven and Catherine Hambly and \{El Hamdouchi\}, Asmaa and Hoos, \{Marjije B.\} and Sumei Hu and Noorjehan Joonas and Joosen, \{Annemiek M.\} and Peter Katzmarzyk and Kempen, \{Kitty P.\} and Misaka Kimura and Kraus, \{William E.\} and Kushner, \{Robert F.\} and Lambert, \{Estelle V.\} and Leonard, \{William R.\} and Nader Lessan and Corby Martin and Medin, \{Anine C.\} and Meijer, \{Erwin P.\} and Morehen, \{James C.\} and Morton, \{James P.\} and Neuhouser, \{Marian L.\} and Nicklas, \{Teresa A.\} and Ojiambo, \{Robert M.\} and Pietil{\"a}inen, \{Kirsi H.\} and Pitsiladis, \{Yannis P.\} and Jacob Plange-Rhule and Guy Plasqui and Prentice, \{Ross L.\} and Rabinovich, \{Roberto A.\} and Racette, \{Susan B.\} and Raichlen, \{David A.\} and Eric Ravussin and Reynolds, \{Rebecca M.\} and Roberts, \{Susan B.\} and Schuit, \{Albertine J.\} and Sj{\"o}din, \{Anders M.\} and Eric Stice and Urlacher, \{Samuel S.\} and Giulio Valenti and \{Van Etten\}, \{Ludo M.\} and Van Mil, \{Edgar A\} and Wells, \{Jonathan C. K.\} and George Wilson and Wood, \{Brian M.\} and Jack Yanovski and Tsukasa Yoshida and Xueying Zhang and Murphy-Alford, \{Alexia J.\} and Cornelia Loechl and Luke, \{Amy H.\} and Jennifer Rood and Schoeller, \{Dale A.\} and Westerterp, \{Klaas R.\} and Wong, \{William W.\} and Speakman, \{John R.\} and \{IAEA DLW Database Consortium\}",

note = "Funding information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript. Publisher Copyright: Copyright {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",

year = "2021",

month = aug,

day = "13",

doi = "10.1126/science.abe5017",

language = "English",

volume = "373",

pages = "808--812",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6556",

}

Pontzer, H, Yamada, Y, Sagayama, H, Ainslie, PN, Andersen, LF, Anderson, LJ, Arab, L, Baddou, I, Bedu-Addo, K, Blaak, EE, Blanc, S, Bonomi, AG, Bouten, CVC, Bovet, P, Buchowski, MS, Butte, NF, Camps, SG, Close, GL, Cooper, JA, Cooper, R, Das, SK, Dugas, LR, Ekelund, U, Entringer, S, Forrester, T, Fudge, BW, Goris, AH, Gurven, M, Hambly, C, El Hamdouchi, A, Hoos, MB, Hu, S, Joonas, N, Joosen, AM, Katzmarzyk, P, Kempen, KP, Kimura, M, Kraus, WE, Kushner, RF, Lambert, EV, Leonard, WR, Lessan, N, Martin, C, Medin, AC, Meijer, EP, Morehen, JC, Morton, JP, Neuhouser, ML, Nicklas, TA, Ojiambo, RM, Pietiläinen, KH, Pitsiladis, YP, Plange-Rhule, J, Plasqui, G, Prentice, RL, Rabinovich, RA, Racette, SB, Raichlen, DA, Ravussin, E, Reynolds, RM, Roberts, SB, Schuit, AJ, Sjödin, AM, Stice, E, Urlacher, SS, Valenti, G, Van Etten, LM, Van Mil, EA, Wells, JCK, Wilson, G, Wood, BM, Yanovski, J, Yoshida, T, Zhang, X, Murphy-Alford, AJ, Loechl, C, Luke, AH, Rood, J, Schoeller, DA, Westerterp, KR, Wong, WW, Speakman, JR & IAEA DLW Database Consortium 2021, 'Daily energy expenditure through the human life course', Science, vol. 373, no. 6556, pp. 808-812. https://doi.org/10.1126/science.abe5017

TY - JOUR

T1 - Daily energy expenditure through the human life course

AU - Pontzer, Herman

AU - Yamada, Yosuke

AU - Sagayama, Hiroyuki

AU - Ainslie, Philip N.

AU - Andersen, Lene F.

AU - Anderson, Liam J.

AU - Arab, Lenore

AU - Baddou, Issaad

AU - Bedu-Addo, Kweku

AU - Blaak, Ellen E.

AU - Blanc, Stephane

AU - Bonomi, Alberto G.

AU - Bouten, Carlijn V. C.

AU - Bovet, Pascal

AU - Buchowski, Maciej S.

AU - Butte, Nancy F.

AU - Camps, Stefan G.

AU - Close, Graeme L.

AU - Cooper, Jamie A.

AU - Cooper, Richard

AU - Das, Sai Krupa

AU - Dugas, Lara R.

AU - Ekelund, Ulf

AU - Entringer, Sonja

AU - Forrester, Terrence

AU - Fudge, Barry W.

AU - Goris, Annelies H

AU - Gurven, Michael

AU - Hambly, Catherine

AU - El Hamdouchi, Asmaa

AU - Hoos, Marjije B.

AU - Hu, Sumei

AU - Joonas, Noorjehan

AU - Joosen, Annemiek M.

AU - Katzmarzyk, Peter

AU - Kempen, Kitty P.

AU - Kimura, Misaka

AU - Kraus, William E.

AU - Kushner, Robert F.

AU - Lambert, Estelle V.

AU - Leonard, William R.

AU - Lessan, Nader

AU - Martin, Corby

AU - Medin, Anine C.

AU - Meijer, Erwin P.

AU - Morehen, James C.

AU - Morton, James P.

AU - Neuhouser, Marian L.

AU - Nicklas, Teresa A.

AU - Ojiambo, Robert M.

AU - Pietiläinen, Kirsi H.

AU - Pitsiladis, Yannis P.

AU - Plange-Rhule, Jacob

AU - Plasqui, Guy

AU - Prentice, Ross L.

AU - Rabinovich, Roberto A.

AU - Racette, Susan B.

AU - Raichlen, David A.

AU - Ravussin, Eric

AU - Reynolds, Rebecca M.

AU - Roberts, Susan B.

AU - Schuit, Albertine J.

AU - Sjödin, Anders M.

AU - Stice, Eric

AU - Urlacher, Samuel S.

AU - Valenti, Giulio

AU - Van Etten, Ludo M.

AU - Van Mil, Edgar A

AU - Wells, Jonathan C. K.

AU - Wilson, George

AU - Wood, Brian M.

AU - Yanovski, Jack

AU - Yoshida, Tsukasa

AU - Zhang, Xueying

AU - Murphy-Alford, Alexia J.

AU - Loechl, Cornelia

AU - Luke, Amy H.

AU - Rood, Jennifer

AU - Schoeller, Dale A.

AU - Westerterp, Klaas R.

AU - Wong, William W.

AU - Speakman, John R.

AU - IAEA DLW Database Consortium

N1 - Funding information: The IAEA Doubly Labeled Water (DLW) Database is generously supported by the IAEA, Taiyo Nippon Sanso, and SERCON. The authors also gratefully acknowledge funding from the US National Science Foundation (BCS-1824466) awarded to H.P. The funders played no role in the content of this manuscript. Publisher Copyright: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2021/8/13

Y1 - 2021/8/13

N2 - Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

AB - Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass–adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

UR - https://www.scopus.com/pages/publications/85112515247

U2 - 10.1126/science.abe5017

DO - 10.1126/science.abe5017

M3 - Journal article

C2 - 34385400

AN - SCOPUS:85112515247

SN - 0036-8075

VL - 373

SP - 808

EP - 812

JO - Science

JF - Science

IS - 6556

ER -

Daily energy expenditure through the human life course

Abstract

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