TY - JOUR
T1 - Cytotoxic triterpenoids from
T2 - Antrodia camphorata as sensitizers of paclitaxel
AU - Li, Bin
AU - Kuang, Yi
AU - Zhang, Meng
AU - He, Jun Bin
AU - Xu, Lu Lu
AU - Leung, Chung Hang
AU - MA, Edmond Dik Lung
AU - Lo, Jen Yu
AU - Qiao, Xue
AU - Ye, Min
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (81725023, 81891010/81891011, and 81921001), the Beijing Natural Science Foundation (JQ18027), and the National Mega-project for Innovative Drugs (2018ZX09711001-008-003).
PY - 2020/3/7
Y1 - 2020/3/7
N2 - In an attempt to discover anticancer triterpenoids from the medicinal fungus Antrodia camphorata, a total of 60 triterpenoids (1-60) including 18 new ones (antcamphins M-X, 1-18) were isolated from its dish cultures. The structures of the new compounds were elucidated by extensive NMR and HRESIMS data analyses. The absolute configurations were established by the modified Mosher's method, chemical transformation, or X-ray crystallographic data analysis. The cytotoxic activities of 1-60, together with previously reported compounds 61-81, were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7 cells). Compound 57 exhibited potent activities against all the four cell lines with IC50 values of 2.6, 8.2, 2.5, and 4.6 μM, respectively. Moreover, the combination of 10 and 69 (20 μM) could remarkably enhance their cytotoxic activities against the HL60 cells of paclitaxel (10 nM), with inhibition rates increasing from 19.6% to 58.2% and 70.6%, respectively.
AB - In an attempt to discover anticancer triterpenoids from the medicinal fungus Antrodia camphorata, a total of 60 triterpenoids (1-60) including 18 new ones (antcamphins M-X, 1-18) were isolated from its dish cultures. The structures of the new compounds were elucidated by extensive NMR and HRESIMS data analyses. The absolute configurations were established by the modified Mosher's method, chemical transformation, or X-ray crystallographic data analysis. The cytotoxic activities of 1-60, together with previously reported compounds 61-81, were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7 cells). Compound 57 exhibited potent activities against all the four cell lines with IC50 values of 2.6, 8.2, 2.5, and 4.6 μM, respectively. Moreover, the combination of 10 and 69 (20 μM) could remarkably enhance their cytotoxic activities against the HL60 cells of paclitaxel (10 nM), with inhibition rates increasing from 19.6% to 58.2% and 70.6%, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85081118749&partnerID=8YFLogxK
U2 - 10.1039/c9qo01516g
DO - 10.1039/c9qo01516g
M3 - Journal article
AN - SCOPUS:85081118749
SN - 2052-4110
VL - 7
SP - 768
EP - 779
JO - Organic Chemistry Frontiers
JF - Organic Chemistry Frontiers
IS - 5
ER -