Cytotoxic tigliane diterpenoids from Euphorbia neorubella

Shuangcheng Chen, Nga Yi Tsang, Haowen Jiang, Hongjie Zhang, Xiang Ge, Yanni Wu, Yu Shen, Wenxia Xie, Jinlong Li*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

1 Citation (Scopus)


Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3–6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC50 values ranging from 1.318 to 7.042 μM.

Original languageEnglish
Pages (from-to)2753-2757
Number of pages5
JournalNatural Product Research
Issue number11
Publication statusPublished - 2 Jun 2022

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

User-Defined Keywords

  • cytotoxicity
  • Euphorbia neorubella
  • tigliane diterpenoids


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