Cytotoxic tigliane diterpenoids from Euphorbia neorubella

Shuangcheng Chen; Nga Yi Tsang; Haowen Jiang; Hongjie Zhang; Xiang Ge; Yanni Wu; Yu Shen; Wenxia Xie; Jinlong Li

doi:10.1080/14786419.2021.1924712

Cytotoxic tigliane diterpenoids from Euphorbia neorubella

Shuangcheng Chen, Nga Yi Tsang, Haowen Jiang, Hongjie Zhang, Xiang Ge, Yanni Wu, Yu Shen, Wenxia Xie, Jinlong Li^*

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3–6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC₅₀ values ranging from 1.318 to 7.042 μM.

Original language	English
Pages (from-to)	2753-2757
Number of pages	5
Journal	Natural Product Research
Volume	36
Issue number	11
DOIs	https://doi.org/10.1080/14786419.2021.1924712
Publication status	Published - 2 Jun 2022

Scopus Subject Areas

Analytical Chemistry
Biochemistry
Plant Science
Organic Chemistry

User-Defined Keywords

cytotoxicity
Euphorbia neorubella
tigliane diterpenoids

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10.1080/14786419.2021.1924712

Cite this

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title = "Cytotoxic tigliane diterpenoids from Euphorbia neorubella",

abstract = "Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3–6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC50 values ranging from 1.318 to 7.042 μM.",

keywords = "cytotoxicity, Euphorbia neorubella, tigliane diterpenoids",

author = "Shuangcheng Chen and Tsang, {Nga Yi} and Haowen Jiang and Hongjie Zhang and Xiang Ge and Yanni Wu and Yu Shen and Wenxia Xie and Jinlong Li",

note = "Funding Information: This work was partial supported by the [National Natural Science Foundation of China] under Grant [81803384], the [Natural Science Foundation of Jiangsu Province] under Grant [BK20180947] and the [Nantong Scientific Research Project] under Grant [JC2019104]. Publisher Copyright: {\textcopyright} 2021 Informa UK Limited, trading as Taylor & Francis Group.",

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doi = "10.1080/14786419.2021.1924712",

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AU - Chen, Shuangcheng

AU - Tsang, Nga Yi

AU - Jiang, Haowen

AU - Zhang, Hongjie

AU - Ge, Xiang

AU - Wu, Yanni

AU - Shen, Yu

AU - Xie, Wenxia

AU - Li, Jinlong

N1 - Funding Information: This work was partial supported by the [National Natural Science Foundation of China] under Grant [81803384], the [Natural Science Foundation of Jiangsu Province] under Grant [BK20180947] and the [Nantong Scientific Research Project] under Grant [JC2019104]. Publisher Copyright: © 2021 Informa UK Limited, trading as Taylor & Francis Group.

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N2 - Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3–6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC50 values ranging from 1.318 to 7.042 μM.

AB - Two new tigliane diterpenes, named eupneonoids A (1) and B (2), together with four known analogues (3–6) were isolated from the whole plant of Euphorbia neorubella Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC50 values ranging from 1.318 to 7.042 μM.

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Cytotoxic tigliane diterpenoids from Euphorbia neorubella

Abstract

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