Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus

Simon Q B HAN; Chunfeng Qiao; Jingzheng Song; Niaoyun Yang; Xinwei Cao; Yong Peng; Dajian Yang; Shilin Chen; Hongxi Xu

doi:10.1002/cbdv.200790083

Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus

Simon Q B HAN
, Chunfeng Qiao
, Jingzheng Song
, Niaoyun Yang
, Xinwei Cao
, Yong Peng
, Dajian Yang
, Shilin Chen
, Hongxi Xu

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

60 Citations (Scopus)

Abstract

Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.

Original language	English
Pages (from-to)	940-946
Journal	Chemistry and Biodiversity
Volume	4
Issue number	5
DOIs	https://doi.org/10.1002/cbdv.200790083
Publication status	Published - May 2007

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SDG 3 Good Health and Well-being

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10.1002/cbdv.200790083

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@article{936b7a1c08624dde988744ab511dd974,

title = "Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus",

abstract = "Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.",

author = "HAN, \{Simon Q B\} and Chunfeng Qiao and Jingzheng Song and Niaoyun Yang and Xinwei Cao and Yong Peng and Dajian Yang and Shilin Chen and Hongxi Xu",

note = "We thank the Hong Kong University Grants Committee Area of Excellence Scheme (AoE/P-03-08), the National 973 Basic Research Program of China (2013CB911302), the National Natural Science Foundation of China (Grant No. 21371145), and the City University of Hong Kong (Projects 9667114, 9667131 and 9667148) for funding support.",

year = "2007",

month = may,

doi = "10.1002/cbdv.200790083",

language = "English",

volume = "4",

pages = "940--946",

journal = "Chemistry and Biodiversity",

issn = "1612-1872",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus

AU - HAN, Simon Q B

AU - Qiao, Chunfeng

AU - Song, Jingzheng

AU - Yang, Niaoyun

AU - Cao, Xinwei

AU - Peng, Yong

AU - Yang, Dajian

AU - Chen, Shilin

AU - Xu, Hongxi

N1 - We thank the Hong Kong University Grants Committee Area of Excellence Scheme (AoE/P-03-08), the National 973 Basic Research Program of China (2013CB911302), the National Natural Science Foundation of China (Grant No. 21371145), and the City University of Hong Kong (Projects 9667114, 9667131 and 9667148) for funding support.

PY - 2007/5

Y1 - 2007/5

N2 - Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.

AB - Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.

UR - https://pubmed.ncbi.nlm.nih.gov/17511007/#affiliation-1

U2 - 10.1002/cbdv.200790083

DO - 10.1002/cbdv.200790083

M3 - Journal article

SN - 1612-1872

VL - 4

SP - 940

EP - 946

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 5

ER -

Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus

Abstract

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