TY - JOUR
T1 - Cytotoxic prenylated phenolic compounds from the twig bark of Garcinia xanthochymus
AU - HAN, Simon Q B
AU - Qiao, Chunfeng
AU - Song, Jingzheng
AU - Yang, Niaoyun
AU - Cao, Xinwei
AU - Peng, Yong
AU - Yang, Dajian
AU - Chen, Shilin
AU - Xu, Hongxi
PY - 2007/5
Y1 - 2007/5
N2 - Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
AB - Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1-3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.
UR - https://pubmed.ncbi.nlm.nih.gov/17511007/#affiliation-1
U2 - 10.1002/cbdv.200790083
DO - 10.1002/cbdv.200790083
M3 - Article
SN - 1612-1872
VL - 4
SP - 940
EP - 946
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 5
ER -
