Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

Quan Bin Han; Yu Lin Wang; Ling Yang; Ting Fai Tso; Chun Feng Qiao; Jing Zheng Song; Li Jia Xu; Shi Lin Chen; Da Jian Yang; Hong Xi Xu

doi:10.1248/cpb.54.265

Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

Quan Bin Han, Yu Lin Wang, Ling Yang, Ting Fai Tso, Chun Feng Qiao, Jing Zheng Song, Li Jia Xu, Shi Lin Chen, Da Jian Yang, Hong Xi Xu^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

Original language	English
Pages (from-to)	265-267
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	54
Issue number	2
DOIs	https://doi.org/10.1248/cpb.54.265
Publication status	Published - Feb 2006

Scopus Subject Areas

Chemistry(all)
Drug Discovery

User-Defined Keywords

Cytotoxicity
Garcinia hanburyi
Gaudichaudic acid
Isogambogenic acid
Multidrug resistance
Xanthone

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10.1248/cpb.54.265

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title = "Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi",

abstract = "Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.",

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author = "Han, {Quan Bin} and Wang, {Yu Lin} and Ling Yang and Tso, {Ting Fai} and Qiao, {Chun Feng} and Song, {Jing Zheng} and Xu, {Li Jia} and Chen, {Shi Lin} and Yang, {Da Jian} and Xu, {Hong Xi}",

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doi = "10.1248/cpb.54.265",

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pages = "265--267",

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T1 - Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

AU - Han, Quan Bin

AU - Wang, Yu Lin

AU - Yang, Ling

AU - Tso, Ting Fai

AU - Qiao, Chun Feng

AU - Song, Jing Zheng

AU - Xu, Li Jia

AU - Chen, Shi Lin

AU - Yang, Da Jian

AU - Xu, Hong Xi

PY - 2006/2

Y1 - 2006/2

N2 - Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

AB - Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

KW - Cytotoxicity

KW - Garcinia hanburyi

KW - Gaudichaudic acid

KW - Isogambogenic acid

KW - Multidrug resistance

KW - Xanthone

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EP - 267

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

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Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

Abstract

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