Abstract
Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.
Original language | English |
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Pages (from-to) | 265-267 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 54 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2006 |
Scopus Subject Areas
- Chemistry(all)
- Drug Discovery
User-Defined Keywords
- Cytotoxicity
- Garcinia hanburyi
- Gaudichaudic acid
- Isogambogenic acid
- Multidrug resistance
- Xanthone