Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi

Quan Bin Han, Yu Lin Wang, Ling Yang, Ting Fai Tso, Chun Feng Qiao, Jing Zheng Song, Li Jia Xu, Shi Lin Chen, Da Jian Yang, Hong Xi Xu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

86 Citations (Scopus)

Abstract

Thirteen xanthones (1-13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 2006

Scopus Subject Areas

  • Chemistry(all)
  • Drug Discovery

User-Defined Keywords

  • Cytotoxicity
  • Garcinia hanburyi
  • Gaudichaudic acid
  • Isogambogenic acid
  • Multidrug resistance
  • Xanthone

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