Cytotoxic hydrolyzable tannins from Balanophora japonica

Zhi Hong JIANG; Xiao Yun Wen; Takashi Tanaka; Shao Yu Wu; Zhongqiu Liu; Hiromi Iwata; Yoko Hirose; Shuguang Wu; Isao Kouno

doi:10.1021/np070519+

Cytotoxic hydrolyzable tannins from Balanophora japonica

Zhi Hong JIANG^*, Xiao Yun Wen, Takashi Tanaka, Shao Yu Wu, Zhongqiu Liu, Hiromi Iwata, Yoko Hirose, Shuguang Wu, Isao Kouno

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Four hydrolyzable tannins named balanophotannins D-G (1-4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D (1) and F (3) were determined via the PGME method. Balanophotannin E (2) showed cytotoxicity to Hep G2 cancer cells with an IC₅₀ value of 4.22 μM.

Original language	English
Pages (from-to)	719-723
Number of pages	5
Journal	Journal of Natural Products
Volume	71
Issue number	4
DOIs	https://doi.org/10.1021/np070519+
Publication status	Published - Apr 2008

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "Four hydrolyzable tannins named balanophotannins D-G (1-4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D (1) and F (3) were determined via the PGME method. Balanophotannin E (2) showed cytotoxicity to Hep G2 cancer cells with an IC50 value of 4.22 μM.",

author = "JIANG, {Zhi Hong} and Wen, {Xiao Yun} and Takashi Tanaka and Wu, {Shao Yu} and Zhongqiu Liu and Hiromi Iwata and Yoko Hirose and Shuguang Wu and Isao Kouno",

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T1 - Cytotoxic hydrolyzable tannins from Balanophora japonica

AU - JIANG, Zhi Hong

AU - Wen, Xiao Yun

AU - Tanaka, Takashi

AU - Wu, Shao Yu

AU - Liu, Zhongqiu

AU - Iwata, Hiromi

AU - Hirose, Yoko

AU - Wu, Shuguang

AU - Kouno, Isao

PY - 2008/4

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AB - Four hydrolyzable tannins named balanophotannins D-G (1-4) were isolated from the aerial parts of the parasitic plant Balanophora japonica. Their structures were characterized on the basis of spectroscopic and chemical evidence. Balanophotannins D-G contain an oxidized hexahydroxydiphenoyl (HHDP) group. The absolute configurations of balanophotannins D (1) and F (3) were determined via the PGME method. Balanophotannin E (2) showed cytotoxicity to Hep G2 cancer cells with an IC50 value of 4.22 μM.

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JO - Journal of Natural Products

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ER -

Cytotoxic hydrolyzable tannins from Balanophora japonica

Abstract

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