Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

Li Mei Li; Zhi Ying Weng; Sheng Xiong Huang; Jian Xin Pu; Sheng Hong Li; Hao Huang; Bing Bing Yang; Yu Han; Wei Lie Xiao; Ma-Lin Li; Quan Bin Han; Han Dong Sun

doi:10.1021/np070205m

Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

Li Mei Li, Zhi Ying Weng, Sheng Xiong Huang, Jian Xin Pu, Sheng Hong Li, Hao Huang, Bing Bing Yang, Yu Han, Wei Lie Xiao, Ma-Lin Li, Quan Bin Han^*, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

30 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilus led to the isolation of a series of potential antitumor molecules. Thirteen new (1-13) and 23 (14-36) known diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1-13 were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16-19, 23, 26-28, 30, and 32 demonstrated significant cytotoxic activity for one or more cell lines.

Original language	English
Pages (from-to)	1295-1301
Number of pages	7
Journal	Journal of Natural Products
Volume	70
Issue number	8
DOIs	https://doi.org/10.1021/np070205m
Publication status	Published - 1 Aug 2007

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np070205m

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@article{46674736847a4604a10a90edbbbb76f1,

title = "Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus",

abstract = "Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilus led to the isolation of a series of potential antitumor molecules. Thirteen new (1-13) and 23 (14-36) known diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1-13 were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16-19, 23, 26-28, 30, and 32 demonstrated significant cytotoxic activity for one or more cell lines.",

author = "Li, {Li Mei} and Weng, {Zhi Ying} and Huang, {Sheng Xiong} and Pu, {Jian Xin} and Li, {Sheng Hong} and Hao Huang and Yang, {Bing Bing} and Yu Han and Xiao, {Wei Lie} and Ma-Lin Li and Han, {Quan Bin} and Sun, {Han Dong}",

note = "Financial support of the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.) is gratefully acknowledged.",

year = "2007",

month = aug,

day = "1",

doi = "10.1021/np070205m",

language = "English",

volume = "70",

pages = "1295--1301",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

AU - Li, Li Mei

AU - Weng, Zhi Ying

AU - Huang, Sheng Xiong

AU - Pu, Jian Xin

AU - Li, Sheng Hong

AU - Huang, Hao

AU - Yang, Bing Bing

AU - Han, Yu

AU - Xiao, Wei Lie

AU - Li, Ma-Lin

AU - Han, Quan Bin

AU - Sun, Han Dong

N1 - Financial support of the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and the National Natural Science Foundation of China (No. 20502026 to Q.-B.H.) is gratefully acknowledged.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilus led to the isolation of a series of potential antitumor molecules. Thirteen new (1-13) and 23 (14-36) known diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1-13 were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16-19, 23, 26-28, 30, and 32 demonstrated significant cytotoxic activity for one or more cell lines.

AB - Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilus led to the isolation of a series of potential antitumor molecules. Thirteen new (1-13) and 23 (14-36) known diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1-13 were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16-19, 23, 26-28, 30, and 32 demonstrated significant cytotoxic activity for one or more cell lines.

UR - https://pubmed.ncbi.nlm.nih.gov/17665952/#affiliation-1

UR - http://www.scopus.com/inward/record.url?scp=34548617819&partnerID=8YFLogxK

U2 - 10.1021/np070205m

DO - 10.1021/np070205m

M3 - Journal article

AN - SCOPUS:34548617819

SN - 0163-3864

VL - 70

SP - 1295

EP - 1301

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

Abstract

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