Cytotoxic ent-kauranoids from the medicinal plant Isodon xerophilus

Li Mei Li, Zhi Ying Weng, Sheng Xiong Huang, Jian Xin Pu, Sheng Hong Li, Hao Huang, Bing Bing Yang, Yu Han, Wei Lie Xiao, Ma-Lin Li, Quan Bin Han*, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

28 Citations (Scopus)

Abstract

Bioassay-directed fractionation of the leaves of the medicinal plant Isodon xerophilus led to the isolation of a series of potential antitumor molecules. Thirteen new (1-13) and 23 (14-36) known diterpenoids were isolated and identified, representing ent-kauranoids of several structural types. The structures of 1-13 were determined by means of spectroscopic studies. The absolute configurations of the new compounds were clarified by CD spectroscopic studies or were postulated on biogenetic grounds. All compounds obtained were evaluated for their cytotoxic activity against the K562, MKN45, and HepG2 cell lines. Compounds 1, 2, 11, 16-19, 23, 26-28, 30, and 32 demonstrated significant cytotoxic activity for one or more cell lines.

Original languageEnglish
Pages (from-to)1295-1301
Number of pages7
JournalJournal of Natural Products
Volume70
Issue number8
DOIs
Publication statusPublished - 1 Aug 2007

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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