Cytotoxic ent-kauranoids from Isodon parvifolius

Li Mei Li, Guo You Li, Sheng Hong Li, Zhi Ying Weng, Wei Lie Xiao, Quan Bin Han, Li Sheng Ding, Li Guang Lou, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

9 Citations (Scopus)


Three new ent-kaurane diterpenoids, parvifoline Z (1), parvifoline AA (2), and parvifoline AB (3), together with 14 known compounds, were isolated from the leaves of Isodon parvifolius. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopy and mass spectrometry, and by comparison with known compounds. These three new diterpenoids included three types of ent-kauranoids, namely, C(20)-non-oxygenated-ent-kauranoid, 7,20-cyclo-ent-kauranoid and 6,7-seco-ent-kauranoid-7,20-olide. Compounds 1 and 2 exhibited significant cytotoxicities against A549, HT-29, and K562 cell lines (Table 2).

Original languageEnglish
Pages (from-to)1031-1038
Number of pages8
JournalChemistry and Biodiversity
Issue number9
Publication statusPublished - 22 Sept 2006

Scopus Subject Areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

User-Defined Keywords

  • Diterpenoids
  • ent-Kaurane diterpenoids
  • Parvifoline Z
  • Parvifoline AA
  • Cytotoxic activity
  • Isodon parvifolius


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