Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Sheng Xiong Huang; Yan Zhou; Jian Xin Pu; Rong Tao Li; Xian Li; Wei Lie Xiao; Li Guang Lou; Quan Bin Han; Li Sheng Ding; Shu Lin Peng; Han Dong Sun

doi:10.1016/j.tet.2006.02.079

Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Sheng Xiong Huang
, Yan Zhou
, Jian Xin Pu
, Rong Tao Li
, Xian Li
, Wei Lie Xiao
, Li Guang Lou
, Quan Bin Han
, Li Sheng Ding
, Shu Lin Peng
, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

36 Citations (Scopus)

Abstract

An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC₅₀ values of <2.0 μM. The structure-activity relationships were discussed.

Original language	English
Pages (from-to)	4941-4947
Number of pages	7
Journal	Tetrahedron
Volume	62
Issue number	20
DOIs	https://doi.org/10.1016/j.tet.2006.02.079
Publication status	Published - 15 May 2006

User-Defined Keywords

Cytotoxicity
ent-Kaurane
Hebeirubescensin
Isodon rubescens

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10.1016/j.tet.2006.02.079

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@article{74d50199c16f4584bc60491675067ff7,

title = "Cytotoxic ent-kauranoid derivatives from Isodon rubescens",

abstract = "An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.",

keywords = "Cytotoxicity, ent-Kaurane, Hebeirubescensin, Isodon rubescens",

author = "Huang, \{Sheng Xiong\} and Yan Zhou and Pu, \{Jian Xin\} and Li, \{Rong Tao\} and Xian Li and Xiao, \{Wei Lie\} and Lou, \{Li Guang\} and Han, \{Quan Bin\} and Ding, \{Li Sheng\} and Peng, \{Shu Lin\} and Sun, \{Han Dong\}",

note = "Funding Information: Financial support of this research was provided by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (no. 20502026 to Q-B. Han). The authors are grateful to Mrs. Xu Zou for collecting the plant material. ",

year = "2006",

month = may,

day = "15",

doi = "10.1016/j.tet.2006.02.079",

language = "English",

volume = "62",

pages = "4941--4947",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "20",

}

TY - JOUR

T1 - Cytotoxic ent-kauranoid derivatives from Isodon rubescens

AU - Huang, Sheng Xiong

AU - Zhou, Yan

AU - Pu, Jian Xin

AU - Li, Rong Tao

AU - Li, Xian

AU - Xiao, Wei Lie

AU - Lou, Li Guang

AU - Han, Quan Bin

AU - Ding, Li Sheng

AU - Peng, Shu Lin

AU - Sun, Han Dong

N1 - Funding Information: Financial support of this research was provided by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (no. 20502026 to Q-B. Han). The authors are grateful to Mrs. Xu Zou for collecting the plant material.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.

AB - An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.

KW - Cytotoxicity

KW - ent-Kaurane

KW - Hebeirubescensin

KW - Isodon rubescens

UR - https://www.scopus.com/pages/publications/33646030300

U2 - 10.1016/j.tet.2006.02.079

DO - 10.1016/j.tet.2006.02.079

M3 - Journal article

SN - 0040-4020

VL - 62

SP - 4941

EP - 4947

JO - Tetrahedron

JF - Tetrahedron

IS - 20

ER -

Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Abstract

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