Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Sheng Xiong Huang, Yan Zhou, Jian Xin Pu, Rong Tao Li, Xian Li, Wei Lie Xiao, Li Guang Lou, Quan Bin Han, Li Sheng Ding, Shu Lin Peng, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

35 Citations (Scopus)


An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.

Original languageEnglish
Pages (from-to)4941-4947
Number of pages7
Issue number20
Publication statusPublished - 15 May 2006

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Cytotoxicity
  • ent-Kaurane
  • Hebeirubescensin
  • Isodon rubescens


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