Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Sheng Xiong Huang; Yan Zhou; Jian Xin Pu; Rong Tao Li; Xian Li; Wei Lie Xiao; Li Guang Lou; Quan Bin Han; Li Sheng Ding; Shu Lin Peng; Han Dong Sun

doi:10.1016/j.tet.2006.02.079

Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Sheng Xiong Huang, Yan Zhou, Jian Xin Pu, Rong Tao Li, Xian Li, Wei Lie Xiao, Li Guang Lou, Quan Bin Han, Li Sheng Ding, Shu Lin Peng, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

36 Citations (Scopus)

Abstract

An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC₅₀ values of <2.0 μM. The structure-activity relationships were discussed.

Original language	English
Pages (from-to)	4941-4947
Number of pages	7
Journal	Tetrahedron
Volume	62
Issue number	20
DOIs	https://doi.org/10.1016/j.tet.2006.02.079
Publication status	Published - 15 May 2006

Scopus Subject Areas

Biochemistry
Drug Discovery
Organic Chemistry

User-Defined Keywords

Cytotoxicity
ent-Kaurane
Hebeirubescensin
Isodon rubescens

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10.1016/j.tet.2006.02.079

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@article{74d50199c16f4584bc60491675067ff7,

title = "Cytotoxic ent-kauranoid derivatives from Isodon rubescens",

abstract = "An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.",

keywords = "Cytotoxicity, ent-Kaurane, Hebeirubescensin, Isodon rubescens",

author = "Huang, {Sheng Xiong} and Yan Zhou and Pu, {Jian Xin} and Li, {Rong Tao} and Xian Li and Xiao, {Wei Lie} and Lou, {Li Guang} and Han, {Quan Bin} and Ding, {Li Sheng} and Peng, {Shu Lin} and Sun, {Han Dong}",

note = "Funding Information: Financial support of this research was provided by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (no. 20502026 to Q-B. Han). The authors are grateful to Mrs. Xu Zou for collecting the plant material. ",

year = "2006",

month = may,

day = "15",

doi = "10.1016/j.tet.2006.02.079",

language = "English",

volume = "62",

pages = "4941--4947",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd.",

number = "20",

}

TY - JOUR

T1 - Cytotoxic ent-kauranoid derivatives from Isodon rubescens

AU - Huang, Sheng Xiong

AU - Zhou, Yan

AU - Pu, Jian Xin

AU - Li, Rong Tao

AU - Li, Xian

AU - Xiao, Wei Lie

AU - Lou, Li Guang

AU - Han, Quan Bin

AU - Ding, Li Sheng

AU - Peng, Shu Lin

AU - Sun, Han Dong

N1 - Funding Information: Financial support of this research was provided by the Natural Science Foundation of Yunnan Province (No. 2004C0008Z) and by the National Natural Science Foundation of China (no. 20502026 to Q-B. Han). The authors are grateful to Mrs. Xu Zou for collecting the plant material.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.

AB - An extensive study of the diterpenoids produced by the species of Isodon rubescens, has led to the isolation of 12 new ent-kaurane diterpenoids, hebeirubescensins A-L (1-12), and 19 known analogues. Their structures were determined on the basis of spectroscopic analysis. Selected compounds were assayed for their inhibitory ability against human A549, HT-29, and K562 cells. Among them, hebeirubescensins B and C exhibited significant cytotoxicity with IC50 values of <2.0 μM. The structure-activity relationships were discussed.

KW - Cytotoxicity

KW - ent-Kaurane

KW - Hebeirubescensin

KW - Isodon rubescens

UR - http://www.scopus.com/inward/record.url?scp=33646030300&partnerID=8YFLogxK

U2 - 10.1016/j.tet.2006.02.079

DO - 10.1016/j.tet.2006.02.079

M3 - Journal article

AN - SCOPUS:33646030300

SN - 0040-4020

VL - 62

SP - 4941

EP - 4947

JO - Tetrahedron

JF - Tetrahedron

IS - 20

ER -

Cytotoxic ent-kauranoid derivatives from Isodon rubescens

Abstract

Scopus Subject Areas

User-Defined Keywords

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