Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata

Bei Jiang, Aijun Hou, Malin Li, Shenghong Li, Simon Quan-Bin Han, Sujun Wang, Zhongwen Lin, Handong Sun

Research output: Contribution to journalJournal articlepeer-review

33 Citations (Scopus)

Abstract

Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodosin (6), epi-nodosinol (7), enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some diterpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24. Compounds 3, 4, 6, 8, and 10 showed significant inhibitory effect toward K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml, while 3 and 6 exhibited potent antitumor activity against T24, but none exhibited cytotoxicity toward the cells of A549.
Original languageEnglish
Pages (from-to)921-925
Number of pages5
JournalPlanta Medica
Volume68
Issue number10
DOIs
Publication statusPublished - 21 Oct 2002

User-Defined Keywords

  • Isodon sculponeata
  • Labiatae
  • diterpenoids
  • sculponeatins F-I
  • cytotoxicity

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