Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Quan Bin Han; Wei Xiang; Rong Tao Li; Ma Lin Li; Si Wei Li; Han Dong Sun

doi:10.1055/s-2004-818922

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Quan Bin Han
, Wei Xiang
, Rong Tao Li
, Ma Lin Li
, Si Wei Li
, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

18 Citations (Scopus)

Abstract

Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC₅₀ values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	Planta Medica
Volume	70
Issue number	3
DOIs	https://doi.org/10.1055/s-2004-818922
Publication status	Published - Mar 2004

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@article{936e791ae9564dc585555d8be3dddd04,

title = "Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens",

abstract = "Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.",

author = "Han, \{Quan Bin\} and Wei Xiang and Li, \{Rong Tao\} and Li, \{Ma Lin\} and Li, \{Si Wei\} and Sun, \{Han Dong\}",

year = "2004",

month = mar,

doi = "10.1055/s-2004-818922",

language = "English",

volume = "70",

pages = "269--272",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "3",

}

TY - JOUR

T1 - Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

AU - Han, Quan Bin

AU - Xiang, Wei

AU - Li, Rong Tao

AU - Li, Ma Lin

AU - Li, Si Wei

AU - Sun, Han Dong

PY - 2004/3

Y1 - 2004/3

N2 - Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

AB - Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

UR - https://www.scopus.com/pages/publications/1842536270

U2 - 10.1055/s-2004-818922

DO - 10.1055/s-2004-818922

M3 - Journal article

SN - 0032-0943

VL - 70

SP - 269

EP - 272

JO - Planta Medica

JF - Planta Medica

IS - 3

ER -

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Abstract

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