Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Quan Bin Han, Wei Xiang, Rong Tao Li, Ma Lin Li, Si Wei Li, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

18 Citations (Scopus)


Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

Original languageEnglish
Pages (from-to)269-272
Number of pages4
JournalPlanta Medica
Issue number3
Publication statusPublished - Mar 2004

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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