Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Quan Bin Han; Wei Xiang; Rong Tao Li; Ma Lin Li; Si Wei Li; Han Dong Sun

doi:10.1055/s-2004-818922

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Quan Bin Han, Wei Xiang, Rong Tao Li, Ma Lin Li, Si Wei Li, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

18 Citations (Scopus)

Abstract

Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC₅₀ values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

Original language	English
Pages (from-to)	269-272
Number of pages	4
Journal	Planta Medica
Volume	70
Issue number	3
DOIs	https://doi.org/10.1055/s-2004-818922
Publication status	Published - Mar 2004

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens",

abstract = "Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.",

author = "Han, {Quan Bin} and Wei Xiang and Li, {Rong Tao} and Li, {Ma Lin} and Li, {Si Wei} and Sun, {Han Dong}",

year = "2004",

month = mar,

doi = "10.1055/s-2004-818922",

language = "English",

volume = "70",

pages = "269--272",

journal = "Planta Medica",

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TY - JOUR

T1 - Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

AU - Han, Quan Bin

AU - Xiang, Wei

AU - Li, Rong Tao

AU - Li, Ma Lin

AU - Li, Si Wei

AU - Sun, Han Dong

PY - 2004/3

Y1 - 2004/3

N2 - Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

AB - Five new ent-kauranoids, xindongnins C-G (1-5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6-10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 μg/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

UR - http://www.scopus.com/inward/record.url?scp=1842536270&partnerID=8YFLogxK

U2 - 10.1055/s-2004-818922

DO - 10.1055/s-2004-818922

M3 - Journal article

SN - 0032-0943

VL - 70

SP - 269

EP - 272

JO - Planta Medica

JF - Planta Medica

IS - 3

ER -

Cytotoxic ent-kaurane diterpenoids from Isodon rubescens var. rubescens

Abstract

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