Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Yong Zhao; Sheng Xiong Huang; Li Bin Yang; Jian Xin Pu; Wei Lie Xiao; Li Mei Li; Chun Lei; Zhi Ying Weng; Quan Bin Han; Han Dong Sun

doi:10.1055/s-0028-1088331

Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Yong Zhao
, Sheng Xiong Huang
, Li Bin Yang
, Jian Xin Pu
, Wei Lie Xiao
, Li Mei Li
, Chun Lei
, Zhi Ying Weng
, Quan Bin Han
, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC₅₀ values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Planta Medica
Volume	75
Issue number	1
DOIs	https://doi.org/10.1055/s-0028-1088331
Publication status	Published - Jan 2009

User-Defined Keywords

Cytotoxicity
ent-kaurane diterpenoid
Isodon henryi
Labiatae

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10.1055/s-0028-1088331

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@article{3d881454d40f4d48b357af35f2a016d2,

title = "Cytotoxic ent-kaurane diterpenoids from Isodon henryi",

abstract = "Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.",

keywords = "Cytotoxicity, ent-kaurane diterpenoid, Isodon henryi, Labiatae",

author = "Yong Zhao and Huang, \{Sheng Xiong\} and Yang, \{Li Bin\} and Pu, \{Jian Xin\} and Xiao, \{Wei Lie\} and Li, \{Li Mei\} and Chun Lei and Weng, \{Zhi Ying\} and Han, \{Quan Bin\} and Sun, \{Han Dong\}",

note = "Financial support from the Natural Science Foundation of the Yunnan Province (No. 2004C0008Z) and from the National Natural Science Foundation of China (No. 20 502 026 to Q.-B. H. and No. 30772 637 to H.-D. Sun) is gratefully acknowledged.",

year = "2009",

month = jan,

doi = "10.1055/s-0028-1088331",

language = "English",

volume = "75",

pages = "65--69",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "1",

}

TY - JOUR

T1 - Cytotoxic ent-kaurane diterpenoids from Isodon henryi

AU - Zhao, Yong

AU - Huang, Sheng Xiong

AU - Yang, Li Bin

AU - Pu, Jian Xin

AU - Xiao, Wei Lie

AU - Li, Li Mei

AU - Lei, Chun

AU - Weng, Zhi Ying

AU - Han, Quan Bin

AU - Sun, Han Dong

N1 - Financial support from the Natural Science Foundation of the Yunnan Province (No. 2004C0008Z) and from the National Natural Science Foundation of China (No. 20 502 026 to Q.-B. H. and No. 30772 637 to H.-D. Sun) is gratefully acknowledged.

PY - 2009/1

Y1 - 2009/1

N2 - Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

AB - Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

KW - Cytotoxicity

KW - ent-kaurane diterpenoid

KW - Isodon henryi

KW - Labiatae

UR - https://www.scopus.com/pages/publications/64749093914

U2 - 10.1055/s-0028-1088331

DO - 10.1055/s-0028-1088331

M3 - Journal article

SN - 0032-0943

VL - 75

SP - 65

EP - 69

JO - Planta Medica

JF - Planta Medica

IS - 1

ER -

Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Abstract

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