Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Yong Zhao, Sheng Xiong Huang, Li Bin Yang, Jian Xin Pu, Wei Lie Xiao, Li Mei Li, Chun Lei, Zhi Ying Weng, Quan Bin Han, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

13 Citations (Scopus)


Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalPlanta Medica
Issue number1
Publication statusPublished - Jan 2009

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

User-Defined Keywords

  • Cytotoxicity
  • ent-kaurane diterpenoid
  • Isodon henryi
  • Labiatae


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