Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Yong Zhao; Sheng Xiong Huang; Li Bin Yang; Jian Xin Pu; Wei Lie Xiao; Li Mei Li; Chun Lei; Zhi Ying Weng; Quan Bin Han; Han Dong Sun

doi:10.1055/s-0028-1088331

Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Yong Zhao, Sheng Xiong Huang, Li Bin Yang, Jian Xin Pu, Wei Lie Xiao, Li Mei Li, Chun Lei, Zhi Ying Weng, Quan Bin Han, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

13 Citations (Scopus)

Abstract

Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC₅₀ values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

Original language	English
Pages (from-to)	65-69
Number of pages	5
Journal	Planta Medica
Volume	75
Issue number	1
DOIs	https://doi.org/10.1055/s-0028-1088331
Publication status	Published - Jan 2009

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

User-Defined Keywords

Cytotoxicity
ent-kaurane diterpenoid
Isodon henryi
Labiatae

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10.1055/s-0028-1088331

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title = "Cytotoxic ent-kaurane diterpenoids from Isodon henryi",

abstract = "Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.",

keywords = "Cytotoxicity, ent-kaurane diterpenoid, Isodon henryi, Labiatae",

author = "Yong Zhao and Huang, {Sheng Xiong} and Yang, {Li Bin} and Pu, {Jian Xin} and Xiao, {Wei Lie} and Li, {Li Mei} and Chun Lei and Weng, {Zhi Ying} and Han, {Quan Bin} and Sun, {Han Dong}",

year = "2009",

month = jan,

doi = "10.1055/s-0028-1088331",

language = "English",

volume = "75",

pages = "65--69",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - Cytotoxic ent-kaurane diterpenoids from Isodon henryi

AU - Zhao, Yong

AU - Huang, Sheng Xiong

AU - Yang, Li Bin

AU - Pu, Jian Xin

AU - Xiao, Wei Lie

AU - Li, Li Mei

AU - Lei, Chun

AU - Weng, Zhi Ying

AU - Han, Quan Bin

AU - Sun, Han Dong

PY - 2009/1

Y1 - 2009/1

N2 - Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

AB - Chromatographic fractionation of the extract of Isodon henryi resulted in the isolation of seven new ent-kaurane diterpenoids, named minheryins A-G (1-7), together with the six known ent-kaurane diterpenoids leukamenin F (8), excisoidesin (9), leukamenin E (10), wangzaozin A (11), pseurata A (12), and racemosin A (13), which were elucidated by spectroscopic analysis. Compounds 7-13 were tested for their cytotoxicity against K562 and HepG2 cell lines, and they all exhibited significant activities with IC50 values <0.50 μg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity.

KW - Cytotoxicity

KW - ent-kaurane diterpenoid

KW - Isodon henryi

KW - Labiatae

UR - http://www.scopus.com/inward/record.url?scp=64749093914&partnerID=8YFLogxK

U2 - 10.1055/s-0028-1088331

DO - 10.1055/s-0028-1088331

M3 - Journal article

SN - 0032-0943

VL - 75

SP - 65

EP - 69

JO - Planta Medica

JF - Planta Medica

IS - 1

ER -

Cytotoxic ent-kaurane diterpenoids from Isodon henryi

Abstract

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