Cytotoxic Constituents of Isodon rubescens var. lushiensis

Quan-Bin Han; Ai-Hua Zhao; Ji.-Xia Zhang; Yang Lu; Li-Li Zhang; Qi-Tai Zheng; Han-Dong Sun

doi:10.1021/np030165w

Cytotoxic Constituents of Isodon rubescens var. lushiensis

Quan-Bin Han
, Ai-Hua Zhao
, Ji.-Xia Zhang
, Yang Lu
, Li-Li Zhang
, Qi-Tai Zheng
, Han-Dong Sun

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

40 Citations (Scopus)

Abstract

Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.

Original language	English
Pages (from-to)	1391-1394
Number of pages	4
Journal	Journal of Natural Products
Volume	66
Issue number	10
DOIs	https://doi.org/10.1021/np030165w
Publication status	Published - 1 Oct 2003

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10.1021/np030165w

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title = "Cytotoxic Constituents of Isodon rubescens var. lushiensis",

abstract = "Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.",

author = "Quan-Bin Han and Ai-Hua Zhao and Ji.-Xia Zhang and Yang Lu and Li-Li Zhang and Qi-Tai Zheng and Han-Dong Sun",

year = "2003",

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T1 - Cytotoxic Constituents of Isodon rubescens var. lushiensis

AU - Han, Quan-Bin

AU - Zhao, Ai-Hua

AU - Zhang, Ji.-Xia

AU - Lu, Yang

AU - Zhang, Li-Li

AU - Zheng, Qi-Tai

AU - Sun, Han-Dong

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.

AB - Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.

UR - https://www.scopus.com/pages/publications/0142218970

U2 - 10.1021/np030165w

DO - 10.1021/np030165w

M3 - Journal article

SN - 0163-3864

VL - 66

SP - 1391

EP - 1394

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 10

ER -

Cytotoxic Constituents of Isodon rubescens var. lushiensis

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