Cytotoxic Constituents of Isodon rubescens var. lushiensis

Quan-Bin Han, Ai-Hua Zhao, Ji.-Xia Zhang, Yang Lu, Li-Li Zhang, Qi-Tai Zheng, Han-Dong Sun

Research output: Contribution to journalJournal articlepeer-review

39 Citations (Scopus)


Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.
Original languageEnglish
Pages (from-to)1391-1394
Number of pages4
JournalJournal of Natural Products
Issue number10
Publication statusPublished - 1 Oct 2003


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