TY - JOUR
T1 - Cytotoxic Constituents of Isodon rubescens var. lushiensis
AU - Han, Quan-Bin
AU - Zhao, Ai-Hua
AU - Zhang, Ji.-Xia
AU - Lu, Yang
AU - Zhang, Li-Li
AU - Zheng, Qi-Tai
AU - Sun, Han-Dong
PY - 2003/10/1
Y1 - 2003/10/1
N2 - Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.
AB - Five new ent-kaurane diterpenoids, ludongnins F-J (1-5), along with 10 known compounds, guidongnins A-C (6-8), angustifolin (9), 6-epiangustifolin (10), sculponeatin J (11), gardenin D, 5,3',4'-trihydroxy-6,7,8-trimethoxyflavone, pedalitin, and quercetin, were isolated from the leaves of Isodon rubescens var. lushiensis. The structures of 1-5 were determined by spectroscopic analysis, as well as X-ray crystallographic analysis of 1. Compounds 1-11 were evaluated against K562 leukemia cells for their cytotoxic effects.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-0142218970&partnerID=MN8TOARS
U2 - 10.1021/np030165w
DO - 10.1021/np030165w
M3 - Journal article
SN - 0163-3864
VL - 66
SP - 1391
EP - 1394
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 10
ER -