@article{05393007d6644e70bd8a01405119dc71,
title = "Cytotoxic and anticoagulative diterpenoid glycosides from Pteris decrescens",
abstract = "Diterpenoids from the genus Pteris have demonstrated consistent anticancer properties. In the present study, five previously undescribed (1-5) and four known diterpenoids (6–9) were isolated from the 95 \% methanol extract of P. decrescens. Among them, decrescensin A (1), represents the first naturally occurring example of a 15(8 → 9)-abeo-ent-kauranoid. The structures of these compounds were established based on their spectroscopic data and single-crystal X-ray diffraction. Compounds 1–9 have been evaluated for their cytotoxic effects against a panel of cancer cell lines including HeLa, HepG2, A549 and SW480. Compound 1 showed significant activity in SW480 cells with an IC50 value of 0.46 μM. In addition, compounds 4 and 6 displayed a mild prolongation effect on activated partial thromboplastin time.",
keywords = "Pteris decrescens, Pteridaceae, Diterpenoid glycosides, Cytotoxic activity, Anticoagulation activity",
author = "Chenliang Zhao and Yaxin Yang and \{Al Mamun\}, Abdullah and Lei Wang and Guangjie Li and Jianghai Ye and Jingjie Zhang and Lutai Pan and Kang He and Juan Zou and Hongjie Zhang",
note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd. Funding Information: This project was supported financially by the National Natural Science Foundation of China (No 82360689), Natural-Scientific Research Program of Department of Education of Guizhou Province, Qianjiaoji [No (2023)070], 2023 Guizhou university of traditional Chinese medicine Xueshu Xiaomiao project (Gui Ke He Xue Shu Xin Miao [2023]-11), Department of Education of Guizhou Province Higher Education Institution Natural Science Research Program, Qianjiaoji [No (2023)115], the Research Grants Council of the Hong Kong Special Administrative Region, China (Project No. 12102219), Hong Kong Baptist University, Research Committee, University Grants Committee of the Hong Kong Special Administrative Region, China (UGC Research Matching Grant Scheme RMGS2019-1-19), and Hong Kong PhD Fellowship Scheme (HKPFS awarded to Abdullah Al Mamun).",
year = "2025",
month = dec,
doi = "10.1016/j.phytochem.2025.114643",
language = "English",
volume = "240",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Ltd.",
}
