Cytotoxic acylphloroglucinol derivatives from the twigs of garcinia cowa

Gang Xu; Winnie L.T. Kan; Yan Zhou; Jing Zheng Song; Quan Bin Han; Chun Feng Qiao; Chi Hin Cho; John A. Rudd; Ge Lin; Hong Xi Xu

doi:10.1021/np9004147

Cytotoxic acylphloroglucinol derivatives from the twigs of garcinia cowa

Gang Xu, Winnie L.T. Kan, Yan Zhou, Jing Zheng Song, Quan Bin Han, Chun Feng Qiao, Chi Hin Cho, John A. Rudd, Ge Lin^*, Hong Xi Xu^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

94 Citations (Scopus)

Abstract

An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.

Original language	English
Pages (from-to)	104-108
Number of pages	5
Journal	Journal of Natural Products
Volume	73
Issue number	2
Early online date	8 Jan 2010
DOIs	https://doi.org/10.1021/np9004147
Publication status	Published - 26 Feb 2010

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Cytotoxic acylphloroglucinol derivatives from the twigs of garcinia cowa",

abstract = "An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.",

author = "Gang Xu and Kan, {Winnie L.T.} and Yan Zhou and Song, {Jing Zheng} and Han, {Quan Bin} and Qiao, {Chun Feng} and Cho, {Chi Hin} and Rudd, {John A.} and Ge Lin and Xu, {Hong Xi}",

note = "This research project was funded by the Hong Kong Jockey Club Charities Trust and supported by a Direct Grant (CUHK 2041445) supported from The Chinese University of Hong Kong. ",

year = "2010",

month = feb,

day = "26",

doi = "10.1021/np9004147",

language = "English",

volume = "73",

pages = "104--108",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Cytotoxic acylphloroglucinol derivatives from the twigs of garcinia cowa

AU - Xu, Gang

AU - Kan, Winnie L.T.

AU - Zhou, Yan

AU - Song, Jing Zheng

AU - Han, Quan Bin

AU - Qiao, Chun Feng

AU - Cho, Chi Hin

AU - Rudd, John A.

AU - Lin, Ge

AU - Xu, Hong Xi

N1 - This research project was funded by the Hong Kong Jockey Club Charities Trust and supported by a Direct Grant (CUHK 2041445) supported from The Chinese University of Hong Kong.

PY - 2010/2/26

Y1 - 2010/2/26

N2 - An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.

AB - An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.

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U2 - 10.1021/np9004147

DO - 10.1021/np9004147

M3 - Journal article

SN - 0163-3864

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Cytotoxic acylphloroglucinol derivatives from the twigs of garcinia cowa

Abstract

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