Cytotoxic acylphloroglucinol derivatives from the twigs of garcinia cowa

Gang Xu, Winnie L.T. Kan, Yan Zhou, Jing Zheng Song, Quan Bin Han, Chun Feng Qiao, Chi Hin Cho, John A. Rudd, Ge Lin*, Hong Xi Xu*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

91 Citations (Scopus)

Abstract

An unusual polyprenylated acylphloroglucinol derivative unsubstituted at C-2 and C-6, garcicowin A (1), together with three other new (garcicowins B-D, 2-4) and nine known analogues, was isolated and characterized from the twigs of Garcinia cowa. The structures of 1-4 were elucidated by interpretation of their spectroscopic data. The compounds isolated were evaluated for their cytotoxicity against two cancer cell lines (HT-29 and HCT116) and against normal colon cells (CCD-18Co), and the results demonstrated their selective toxicity toward the cancer cells.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalJournal of Natural Products
Volume73
Issue number2
Early online date8 Jan 2010
DOIs
Publication statusPublished - 26 Feb 2010

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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